Transcription factors FOXO in the regulation of homeostatic hematopoiesis

Vijay Menon, Saghi Ghaffari

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Purpose of review Work in the past decade has revealed key functions of the evolutionary conserved transcription factors Forkhead box O (FOXO) in the maintenance of homeostatic hematopoiesis. Here the diverse array of FOXO functions in normal and diseased hematopoietic stem and progenitor cells is reviewed and the main findings in the past decade are highlighted. Future work should reveal FOXO-regulated networks whose alterations contribute to hematological disorders. Recent findings Recent studies have identified unanticipated FOXO functions in hematopoiesis including in hematopoietic stem and progenitor cells (HSPC), erythroid cells, and immune cells. These findings suggest FOXO3 is critical for the regulation of mitochondrial and metabolic processes in hematopoietic stem cells, the balanced lineage determination, the T and B homeostasis, and terminal erythroblast maturation and red blood cell production. In aggregate these findings highlight the context-dependent function of FOXO in hematopoietic cells. Recent findings also question the nature of FOXO's contribution to heme malignancies as well as the mechanisms underlying FOXO's regulation in HSPC. Summary FOXO are safeguards of homeostatic hematopoiesis. FOXO networks and their regulators and coactivators in HSPC are greatly complex and less well described. Identifications and characterizations of these FOXO networks in disease are likely to uncover disease-promoting mechanisms.

Original languageEnglish
Pages (from-to)290-298
Number of pages9
JournalCurrent Opinion in Hematology
Issue number4
StatePublished - 1 Jul 2018


  • Erythropoiesis
  • Forkhead Box O Transcription Factors
  • Forkhead Box O3
  • Hematologic Malignancies
  • Hematopoietic Stem Cells
  • Immune T And B Cells


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