Transcranial magnetic stimulation and obsessive-compulsive disorder: Current and future approaches

Stefano Pallanti, Alberto Picchi, Andrea Cantisani, Giacomo Grassi

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


It is estimated that up to 30-40 % of patients with obsessive-compulsive disorder (OCD) do not respond to the actual treatments. OCD a very disabling condition, that substantially worsens the quality of life; hence the urgent need to find new therapeutic tools. Different neuromodulation techniques have been studied for the therapy of OCD; the Vagus-nerve stimulation (VNS), the Deep Brain Stimulation (DBS), and the Transcranial Magnetic Stimulation (TMS). While VNS seems to be ineffective in OCD, good results have been reported with DBS, which however remains an invasive procedure. TMS has the advantage to show a good tolerance profile and very few side effects, though its use needs more studies to evaluate its effectiveness and to determine which are the most suitable neuroanatomical targets of stimulation. The aims of this chapter are to review the results of several studies led in these years on the efficacy of Transcranial Magnetic Stimulation (TMS) in the therapy of Obsessive-Compulsive Disorder (OCD).

Original languageEnglish
Title of host publicationTranscranial Magnetic Stimulation
Subtitle of host publicationMethods, Clinical Uses and Effects on the Brain
PublisherNova Science Publishers, Inc.
Number of pages12
ISBN (Print)9781626186798
StatePublished - 2013


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