Trafficking cascades mediated by Rab35 and its membrane hub effector, MICAL-L1

Sai Srinivas Panapakkam Giridharan, Bishuang Cai, Naava Naslavsky, Steve Caplan

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Various receptors navigate through the endocytic recycling compartment (ERC) on route to the plasma membrane. They are transported through recycling endosomes that emanate from the ERC that display distinct tubular morphology. A key question in the field is how the trafficking via these endosomes is regulated and how regulatory proteins such as Rab35, Rab8, Arf6 and EHD1 control this trafficking. Recent studies point to the protein MICAL-L1 as a major scaffold for these regulators. MICAL-L1 not only localizes to these tubular recycling endosomes and regulates trafficking, but it also controls the localization of EHD1 and Rab8 to these structures. It also connects its associated membranes to the motor proteins dynein and kinesin through its binding partner, CRMP2. Our recent study promotes MICAL-L1 as a Rab35 effector, where Rab35, both directly and indirectly through Arf6, controls the localization of MICAL-L1 and Rab8 to tubular membranes. We find that MICAL-L1 is a multi-tasking scaffold connecting various proteins to recycling endosomes for efficient trafficking.

Original languageEnglish
Pages (from-to)384-387
Number of pages4
JournalCommunicative and Integrative Biology
Issue number4
StatePublished - 2012
Externally publishedYes


  • Arf6
  • Endocytic recycling compartment
  • MICAL-L1
  • Rab35
  • Rab8
  • Tubular endosomes


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