Tracking Normalization of Brain Tumor Vasculature by Magnetic Imaging and Proangiogenic Biomarkers

Adília Hormigo, Philip H. Gutin, Shahin Rafii

Research output: Contribution to journalShort surveypeer-review

35 Scopus citations

Abstract

Clinical assessment of the response to antiangiogenic therapy has been cumbersome. A study in this issue of Cancer Cell demonstrates that a combination of magnetic resonance imaging (MRI) for quantification of normalized vessels with measurements of circulating levels of proangiogenic factors, including FGF2, SDF1, and viable circulating endothelial cells, provides an effective means to evaluate the response of recurrent glioblastoma to a prototypical pan-VEGF receptor tyrosine kinase inhibitor, AZD2171.

Original languageEnglish
Pages (from-to)6-8
Number of pages3
JournalCancer Cell
Volume11
Issue number1
DOIs
StatePublished - Jan 2007
Externally publishedYes

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