Trabeculectomy with 5-fluorouracil for adult inflammatory glaucoma

H. D. Jampel, D. A. Jabs, H. A. Quigley

Research output: Contribution to journalArticlepeer-review

106 Scopus citations


We reviewed the records of 12 eyes of ten adult patients with inflammatory glaucoma who underwent trabeculectomy with the adjuvant use of 5-fluorouracil between January 1986 and January 1989. Intraocular pressure decreased from 36 ± 10 mm Hg (range, 17 to 50 mm Hg) preoperatively to 11 ± 4 mm Hg (range, 3 to 17 mm Hg) postoperatively after a median follow-up of 7.75 months (range, six to 38 months). All eyes achieved an intraocular pressure of <20 mm Hg, and ten of 12 required no intraocular pressure lowering medications. The mean (± S.D.) amount of 5-fluorouracil used was 33 ± 10 mg (range, 20 to 55 mg). During the period of observation, five of 12 eyes had an episode of uveitis, but in no patient did this result in loss of intraocular pressure control. Preoperative and postoperative systemic and topical corticosteroid use was the same. Trabeculectomy with 5-fluorouracil is an effective treatment for selected cases of adult inflammatory glaucoma refractory to medical management.

Original languageEnglish
Pages (from-to)168-173
Number of pages6
JournalAmerican Journal of Ophthalmology
Issue number2
StatePublished - 1990
Externally publishedYes


Dive into the research topics of 'Trabeculectomy with 5-fluorouracil for adult inflammatory glaucoma'. Together they form a unique fingerprint.

Cite this