TY - GEN
T1 - Trabecular rods have higher levels of non-enzymatic glycation than plates
AU - Karim, Lamya
AU - Vashishth, Deepak
PY - 2011
Y1 - 2011
N2 - Non-enzymatic glycation (NEG) detrimentally affects cancellous bone's mechanical integrity. In particular, it may help explain the fragility of osteoporotic bone, which is composed primarily of thinner and more rod-like trabeculae. Hence, the goal of our project was to investigate the relationship between the extent of NEG and trabecular morphology. Individual trabeculae were extracted from mechanically tested and stained human cancellous bone. They were imaged using microcomputed tomography, and both trabecular shape and microdamage morphology were characterized. The extent of NEG was measured in each trabeculae and tested for correlation with trabecular structure. Results indicated that more rod-like trabeculae formed crack-like microdamage (p<0.05) and had a trend for higher NEG content (p=0.20) than plate-like trabeculae. These data suggest that the high glycation level in trabecular rods and the presence of harmful linear microcracks weaken the trabecular network present in osteoporotic bone.
AB - Non-enzymatic glycation (NEG) detrimentally affects cancellous bone's mechanical integrity. In particular, it may help explain the fragility of osteoporotic bone, which is composed primarily of thinner and more rod-like trabeculae. Hence, the goal of our project was to investigate the relationship between the extent of NEG and trabecular morphology. Individual trabeculae were extracted from mechanically tested and stained human cancellous bone. They were imaged using microcomputed tomography, and both trabecular shape and microdamage morphology were characterized. The extent of NEG was measured in each trabeculae and tested for correlation with trabecular structure. Results indicated that more rod-like trabeculae formed crack-like microdamage (p<0.05) and had a trend for higher NEG content (p=0.20) than plate-like trabeculae. These data suggest that the high glycation level in trabecular rods and the presence of harmful linear microcracks weaken the trabecular network present in osteoporotic bone.
UR - https://www.scopus.com/pages/publications/79958696974
U2 - 10.1109/NEBC.2011.5778601
DO - 10.1109/NEBC.2011.5778601
M3 - Conference contribution
AN - SCOPUS:79958696974
SN - 9781612848273
T3 - 2011 IEEE 37th Annual Northeast Bioengineering Conference, NEBEC 2011
BT - 2011 IEEE 37th Annual Northeast Bioengineering Conference, NEBEC 2011
T2 - 37th Annual Northeast Bioengineering Conference, NEBEC 2011
Y2 - 1 April 2011 through 3 April 2011
ER -