TPA-induced neurite formation in a neuroblastoma cell line (SH-SY5Y) is associated with increased IGF-I receptor mRNA and binding

Akira Ota; Zila Shen-Orr; Charles T. Roberts; Derek Leroith

doi:10.1016/0169-328X(89)90030-2

TPA-induced neurite formation in a neuroblastoma cell line (SH-SY5Y) is associated with increased IGF-I receptor mRNA and binding

Akira Ota
, Zila Shen-Orr
, Charles T. Roberts
, Derek Leroith

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

The neuroblastoma cell line SH-SY5Y was cultured in the presence of TPA for three days. Increased neurite formation was noted as early as 24 hours after TPA was added. These changes were associated with an increase in IGF-I receptor binding as well as increased mRNA for the IGF-I receptor.

Original language	English
Pages (from-to)	69-76
Number of pages	8
Journal	Molecular Brain Research
Volume	6
Issue number	1
DOIs	https://doi.org/10.1016/0169-328X(89)90030-2
State	Published - Jul 1989
Externally published	Yes

Keywords

12-O-Tetradecanoyl-phorbol-13-acetate
Insulin-like growth factor I
Neuroblastoma
mRNA

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10.1016/0169-328X(89)90030-2

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@article{3264c6d5ec4944cf808dae9ad3a58ec7,

title = "TPA-induced neurite formation in a neuroblastoma cell line (SH-SY5Y) is associated with increased IGF-I receptor mRNA and binding",

abstract = "The neuroblastoma cell line SH-SY5Y was cultured in the presence of TPA for three days. Increased neurite formation was noted as early as 24 hours after TPA was added. These changes were associated with an increase in IGF-I receptor binding as well as increased mRNA for the IGF-I receptor.",

keywords = "12-O-Tetradecanoyl-phorbol-13-acetate, Insulin-like growth factor I, Neuroblastoma, mRNA",

author = "Akira Ota and Zila Shen-Orr and Roberts, \{Charles T.\} and Derek Leroith",

note = "Funding Information: We would like to thank Violet Katz for secretarial help and Drs. Robert Waldbillig and Lars Terenius for help with the manuscript. This work was supported in part by a grant to C.T.R. from the American Diabetes Association, Washington, DC, Affiliate.",

year = "1989",

month = jul,

doi = "10.1016/0169-328X(89)90030-2",

language = "English",

volume = "6",

pages = "69--76",

journal = "Molecular Brain Research",

issn = "0169-328X",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - TPA-induced neurite formation in a neuroblastoma cell line (SH-SY5Y) is associated with increased IGF-I receptor mRNA and binding

AU - Ota, Akira

AU - Shen-Orr, Zila

AU - Roberts, Charles T.

AU - Leroith, Derek

N1 - Funding Information: We would like to thank Violet Katz for secretarial help and Drs. Robert Waldbillig and Lars Terenius for help with the manuscript. This work was supported in part by a grant to C.T.R. from the American Diabetes Association, Washington, DC, Affiliate.

PY - 1989/7

Y1 - 1989/7

N2 - The neuroblastoma cell line SH-SY5Y was cultured in the presence of TPA for three days. Increased neurite formation was noted as early as 24 hours after TPA was added. These changes were associated with an increase in IGF-I receptor binding as well as increased mRNA for the IGF-I receptor.

AB - The neuroblastoma cell line SH-SY5Y was cultured in the presence of TPA for three days. Increased neurite formation was noted as early as 24 hours after TPA was added. These changes were associated with an increase in IGF-I receptor binding as well as increased mRNA for the IGF-I receptor.

KW - 12-O-Tetradecanoyl-phorbol-13-acetate

KW - Insulin-like growth factor I

KW - Neuroblastoma

KW - mRNA

UR - https://www.scopus.com/pages/publications/0024342707

U2 - 10.1016/0169-328X(89)90030-2

DO - 10.1016/0169-328X(89)90030-2

M3 - Article

C2 - 2770453

AN - SCOPUS:0024342707

SN - 0169-328X

VL - 6

SP - 69

EP - 76

JO - Molecular Brain Research

JF - Molecular Brain Research

IS - 1

ER -

TPA-induced neurite formation in a neuroblastoma cell line (SH-SY5Y) is associated with increased IGF-I receptor mRNA and binding

Abstract

Keywords

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