Toxicity of E. coli L‐asparaginase in man

Herbert F. Oettgen, Phyllis A. Stephenson, Morton K. Schwartz, Robert D. Leeper, Lisa Tallal, Charlotte C. Tan, Bayard D. Clarkson, Robert B. Golbey, Irwin H. Krakoff, David A. Karnofsky, M. Lois Murphy, Joseph H. Burchenal

Research output: Contribution to journalArticlepeer-review

257 Scopus citations


During therapeutic trials with E. coli L‐asparaginase in 131 children and 143 adults with neoplastic disease the following signs of toxicity have been observed: fever, nausea and vomiting, weight loss, somnolence, lethargy, confusion, hypolipidemia, hyperlipidemia, hypoproteinemia, abnormal liver function tests, fatty metamorphosis of the liver, pancreatitis (in rare instances), azotemia, granulocytopenia, lymphopenia, thrombocytopenia, and hypersensitivity reactions. While these effects have been moderately severe and reversible in most instances, some patients have shown dangerous degrees of toxicity. This has been the case most frequently in adult patients receiving a dose of 5000 IU/kg/day.

Original languageEnglish
Pages (from-to)253-278
Number of pages26
Issue number2
StatePublished - Feb 1970
Externally publishedYes


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