Toxicity and pharmacokinetics of isolated lung perfusion with cisplatin in rat

Y. Kaneda, D. Liu, A. Brooks, A. Abolhoda, D. Labow, M. E. Burt, R. J. Ginsberg

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

OBJECTIVE: This study was designed to evaluate the toxicity and the pharmacokinetics of cisplatin administered via isolated lung perfusion in Fischer 344 rat. METHODS: Toxicity study; Cisplatin dosages of 3.3, 5.0, 6.7, and 10.0 mg/kg were injected intravenously in four groups, respectively. Cisplatin dosages of 3.3, 5.0, and 6.7 mg/kg were perfused via isolated lung perfusion in a further three groups, respectively. The maximum tolerated dosage of cisplatin was determined by assessing the survival rate on day 21. Pharmacokinetics study; Animals received 6.7 mg/kg of cisplatin intravenously or 3.3 mg/kg of cisplatin via isolated lung perfusion. The cisplatin levels of the lung were measured by flameless atomic spectrometry. RESULTS: Toxicity study; The maximum tolerated dosage of cisplatin via intravenous injection was 6.7 mg/kg, and via isolated lung perfusion was 3.3 mg/kg. Pharmacokinetics study; The cisplatin level in the perfused lung was significantly higher than that in the lung of the animal treated intravenously (16.6 +/- 6.2 micrograms/g of tissue and 7.5 +/- 3.2 micrograms/g of tissue, respectively) (p = 0.0096). CONCLUSION: Isolated lung perfusion with 3.3 mg/kg of cisplatin was pharmacokinetically superior to the maximum tolerated intravenous injection of cisplatin.

Original languageEnglish
Pages (from-to)443-448
Number of pages6
JournalGeneral Thoracic and Cardiovascular Surgery
Volume49
Issue number7
DOIs
StatePublished - Jul 2001
Externally publishedYes

Fingerprint

Dive into the research topics of 'Toxicity and pharmacokinetics of isolated lung perfusion with cisplatin in rat'. Together they form a unique fingerprint.

Cite this