TY - JOUR
T1 - Toxic pediatric parkinsonism
T2 - Report of a child with metabolic studies and response to treatment
AU - Chutorian, Abe M.
AU - Bojko, Aviva
AU - Heier, Linda
AU - Frucht, Steven
AU - Nygaard, Toby
AU - Edelberg, David
PY - 2003/11
Y1 - 2003/11
N2 - We successfully treated a child with parkinsonism secondary to cytosine arabinoside with levodopa/carbidopa and attempted to elucidate the pathogenesis of the disorder by sequential analysis of cerebrospinal fluid biogenic amines, sequential magnetic resonance imaging, and fluorodopa positron emission tomography, which revealed both permanent and reversible biochemical and structural alterations. The parkinsonian disorder resolved in 9 months. Metabolic changes and structural abnormalities on imaging studies were chronologically correlated with the clinical course.
AB - We successfully treated a child with parkinsonism secondary to cytosine arabinoside with levodopa/carbidopa and attempted to elucidate the pathogenesis of the disorder by sequential analysis of cerebrospinal fluid biogenic amines, sequential magnetic resonance imaging, and fluorodopa positron emission tomography, which revealed both permanent and reversible biochemical and structural alterations. The parkinsonian disorder resolved in 9 months. Metabolic changes and structural abnormalities on imaging studies were chronologically correlated with the clinical course.
UR - http://www.scopus.com/inward/record.url?scp=0347513289&partnerID=8YFLogxK
U2 - 10.1177/08830738030180111701
DO - 10.1177/08830738030180111701
M3 - Article
C2 - 14696914
AN - SCOPUS:0347513289
SN - 0883-0738
VL - 18
SP - 812
EP - 815
JO - Journal of Child Neurology
JF - Journal of Child Neurology
IS - 11
ER -