TY - JOUR
T1 - Towards molecular mechanisms for gamete adhesion and fusion during mammalian fertilization
AU - Wassarman, Paul M.
PY - 1995
Y1 - 1995
N2 - The process of fertilization is fundamental to the maintenance of life. The ability of unfertilized eggs and free-swimming sperm to recognize, adhere to, and fuse with each other are vital aspects of the fertilization process. Significant progress has been made recently in identifying and characterizing (glyco)proteins that are associated with the surface of mammalian gametes and that support adhesion and fusion of eggs and sperm. As a result, there are currently reasons to believe that, in mammals, species-specific gamete adhesion is carbohydrate-mediated and gamete fusion is integrin-mediated.
AB - The process of fertilization is fundamental to the maintenance of life. The ability of unfertilized eggs and free-swimming sperm to recognize, adhere to, and fuse with each other are vital aspects of the fertilization process. Significant progress has been made recently in identifying and characterizing (glyco)proteins that are associated with the surface of mammalian gametes and that support adhesion and fusion of eggs and sperm. As a result, there are currently reasons to believe that, in mammals, species-specific gamete adhesion is carbohydrate-mediated and gamete fusion is integrin-mediated.
UR - http://www.scopus.com/inward/record.url?scp=0029122317&partnerID=8YFLogxK
U2 - 10.1016/0955-0674(95)80107-3
DO - 10.1016/0955-0674(95)80107-3
M3 - Article
C2 - 8573340
AN - SCOPUS:0029122317
SN - 0955-0674
VL - 7
SP - 658
EP - 664
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 5
ER -