@inproceedings{648b2121392a45bdb10379778b22b1a6,
title = "Towards intelligent integration and sharing of stem cell research data",
abstract = "Advancements in regenerative medicine have brought to the fore the need for increased standardization and sharing of stem cell product characterization to help drive these innovative interventions toward public availability. Although numerous attempts have been made to store this data, there is still a lack of a platform that incorporates heterogeneous stem cell information into a harmonized project-based framework. The aim of this project was to introduce and pilot-test an intelligent informatics solution which integrates diverse stem cell product characteristics with study subject and omics information. In the resulting platform, heterogeneous data is validated using predefined ontologies and stored in a NoSQL repository. Pilot-testing was performed on nine sponsored stem cell projects conducting preclinical and intervention evaluations. The pilot-testing demonstrated the robustness of the proposed platform, by seamlessly harmonizing diverse common data elements, and the potential of this platform for driving knowledge generation from the aggregation of this shared data.",
keywords = "Data aggregation, common data elements, regenerative medicine, stem cells",
author = "Kirill Borziak and Tianye Qi and Evangelista, {John Erol} and Clarke, {Daniel J.B.} and Avi Ma'Ayan and Joseph Finkelstein",
note = "Funding Information: Data for ReMeDy pilot-testing, in the format of the previously described multi-modular Common Data Elements (CDE) framework [4-5], was obtained from eight projects recently funded by the National Institutes of Health, plus a previously completed clinical trial, {"}Intramyocardial Injection of Mesenchymal Precursor Cells and Successful Temporary Weaning From Left Ventricular Assist Device Support in Patients With Advanced Heart Failure: A Randomized Clinical Trial{"}, that was part of the Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine grant (Project Number: 7U01HL088942-03). The multimodular CDE template for stem cell research data sharing was populated using information available through NIH RePORTER and relevant papers published by the awarded project investigators. A representative set of 30 patients from trial 7U01HL088942-03 were included to populate the study subjects{\textquoteright} section of ReMeDy. This included baseline, outcome, adverse events and readmission information previously submitted to BioLINCC. Publisher Copyright: {\textcopyright} 2020 The authors and IOS Press.",
year = "2020",
doi = "10.3233/SHTI200563",
language = "English",
series = "Studies in Health Technology and Informatics",
publisher = "IOS Press",
pages = "334--337",
editor = "John Mantas and Arie Hasman and Househ, {Mowafa S.} and Parisis Gallos and Emmanouil Zoulias",
booktitle = "THE IMPORTANCE OF HEALTH INFORMATICS IN PUBLIC HEALTH DURING A PANDEMIC",
address = "United States",
}