Toward comprehensive value assessment for Alzheimer's disease innovations

Phyllis B. Ferrell, Howard Fillit, Peter J. Neumann, J. K. Wall, James F. Murray

Research output: Contribution to journalArticlepeer-review


Introduction: Assessing medical technologies for Alzheimer's disease (AD) creates challenges for current methods of value assessment. New value assessment approaches for AD are also needed. Methods: We adapted concepts from health economics to help guide decision makers to more informed decisions about AD therapies and diagnostics. Results: We propose a value framework based on five categories: perspective, value elements, analysis, reporting, and decision making. AD value assessments should include the perspective of the patient–caregiver dyad. We propose a broader array of value elements than currently used. Analytics and decision methods can synthesize evidence for all elements of value. Decisions should use a “deliberative appraisal” approach informed by the composite evidence and be transparently reported. Discussion: Using the proposed framework, the value of forthcoming innovations for AD may be more thoroughly assessed for and by all stakeholders. It can guide decision makers to carefully consider all relevant elements of value contributing to more holistic and transparent decision making. Research Highlights: Alzheimer's disease challenges common methods of evaluating medical technology. Using current methods, new AD innovations might not be appropriately valued. Poor value assessments will adversely affect patient access to AD innovations. A full AD value framework expands perspective, elements, analysis, decision-making, reporting.

Original languageEnglish
Pages (from-to)1558-1567
Number of pages10
JournalAlzheimer's and Dementia
Issue number4
StatePublished - Apr 2023


  • Alzheimer's disease
  • deliberative appraisal
  • elements of value
  • evidence dashboards
  • health technology assessment
  • multi-criteria decision analysis
  • patient–caregiver perspective
  • value analytics
  • value assessment
  • value framework
  • value measures


Dive into the research topics of 'Toward comprehensive value assessment for Alzheimer's disease innovations'. Together they form a unique fingerprint.

Cite this