Total synthesis of caminoside B, a novel antimicrobial glycolipid isolated from the marine sponge Caminus sphaeroconia

Zaihong Zhang, Chengli Zong, Gaopeng Song, Guokai Lv, Yuexing Chun, Peng Wang, Ning Ding, Yingxia Li

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The first total synthesis of caminoside B, a novel marine antimicrobial glycolipid isolated from the marine sponge Caminus sphaeroconia, was developed. This marine small molecule inhibitor (IC50 = 20 μM) targeting type III secretory pathway of bacterial pathogenesis was assembled in good yield via a '2+2+1' strategy based on stereocontrolled construction of the four glycosidic linkages.

Original languageEnglish
Pages (from-to)750-760
Number of pages11
JournalCarbohydrate Research
Volume345
Issue number6
DOIs
StatePublished - 19 Apr 2010
Externally publishedYes

Keywords

  • Antimicrobial glycolipid
  • Caminoside B
  • Regioselective glycosylation
  • Type III secretory pathway

Fingerprint

Dive into the research topics of 'Total synthesis of caminoside B, a novel antimicrobial glycolipid isolated from the marine sponge Caminus sphaeroconia'. Together they form a unique fingerprint.

Cite this