Total synthesis and stereochemical reassignment of tasiamide

Zhen Hua Ma; Ni Song; Chun Xia Li; Wei Zhang; Peng Wang; Ying Xia Li

doi:10.1002/psc.1051

Total synthesis and stereochemical reassignment of tasiamide

Zhen Hua Ma
, Ni Song
, Chun Xia Li
, Wei Zhang
, Peng Wang
, Ying Xia Li

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The total synthesis of a marine acyclic peptide tasiamide and three diastereomers was reported for the first time. The synthesis has led to a reassignment of the N^α-Me-L-Gln of.tasiamide to be Nα-Me-D-Gln, which was supported by ¹H NMR, ¹³C NMR, COSY, HMQC, HMBC, and optical rotation.

Original language	English
Pages (from-to)	1139-1147
Number of pages	9
Journal	Journal of Peptide Science
Volume	14
Issue number	10
DOIs	https://doi.org/10.1002/psc.1051
State	Published - Oct 2008
Externally published	Yes

Keywords

Diastereomer
Reassignment
Synthesis
Tasiamide

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10.1002/psc.1051

Cite this

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title = "Total synthesis and stereochemical reassignment of tasiamide",

abstract = "The total synthesis of a marine acyclic peptide tasiamide and three diastereomers was reported for the first time. The synthesis has led to a reassignment of the Nα-Me-L-Gln of.tasiamide to be Nα-Me-D-Gln, which was supported by 1H NMR, 13C NMR, COSY, HMQC, HMBC, and optical rotation.",

keywords = "Diastereomer, Reassignment, Synthesis, Tasiamide",

author = "Ma, \{Zhen Hua\} and Ni Song and Li, \{Chun Xia\} and Wei Zhang and Peng Wang and Li, \{Ying Xia\}",

year = "2008",

month = oct,

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volume = "14",

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journal = "Journal of Peptide Science",

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AU - Ma, Zhen Hua

AU - Song, Ni

AU - Li, Chun Xia

AU - Zhang, Wei

AU - Wang, Peng

AU - Li, Ying Xia

PY - 2008/10

Y1 - 2008/10

N2 - The total synthesis of a marine acyclic peptide tasiamide and three diastereomers was reported for the first time. The synthesis has led to a reassignment of the Nα-Me-L-Gln of.tasiamide to be Nα-Me-D-Gln, which was supported by 1H NMR, 13C NMR, COSY, HMQC, HMBC, and optical rotation.

AB - The total synthesis of a marine acyclic peptide tasiamide and three diastereomers was reported for the first time. The synthesis has led to a reassignment of the Nα-Me-L-Gln of.tasiamide to be Nα-Me-D-Gln, which was supported by 1H NMR, 13C NMR, COSY, HMQC, HMBC, and optical rotation.

KW - Diastereomer

KW - Reassignment

KW - Synthesis

KW - Tasiamide

UR - https://www.scopus.com/pages/publications/57849127949

U2 - 10.1002/psc.1051

DO - 10.1002/psc.1051

M3 - Article

C2 - 18618900

AN - SCOPUS:57849127949

SN - 1075-2617

VL - 14

SP - 1139

EP - 1147

JO - Journal of Peptide Science

JF - Journal of Peptide Science

IS - 10

ER -

Total synthesis and stereochemical reassignment of tasiamide

Abstract

Keywords

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