TorsinA accumulation in Lewy bodies in sporadic Parkinson's disease

P. Shashidharan; P. F. Good; A. Hsu; D. P. Perl; M. F. Brin; C. W. Olanow

doi:10.1016/S0006-8993(00)02702-5

TorsinA accumulation in Lewy bodies in sporadic Parkinson's disease

P. Shashidharan, P. F. Good, A. Hsu, D. P. Perl, M. F. Brin, C. W. Olanow

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Abstract

Parkinson's disease (PD) is a neurodegnerative disorder that is pathologically characterized by the presence of Lewy bodies in the brain. We show that Lewy bodies in PD are strongly immunoreactive for torsinA, the protein product of the DYT1 gene, which is associated with primary generalized dystonia. In the substantia nigra, torsinA immunoreactivity is localized to the periphery of Lewy bodies, whereas, in cortical Lewy bodies it is uniformly distributed. The significance of this finding is unknown, but may implicate torsinA in neuronal dysfunction that occurs in PD as well as in primary dystonia. (C) 2000 Elsevier Science B.V.

Original language	English
Pages (from-to)	379-381
Number of pages	3
Journal	Brain Research
Volume	877
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(00)02702-5
State	Published - 22 Sep 2000

Keywords

Lewy bodies
Parkinson's disease
Torsion dystonia
α-synuclein

Access to Document

10.1016/S0006-8993(00)02702-5

Cite this

@article{25e2deb8928143399b7056cd8bf7b1c5,

title = "TorsinA accumulation in Lewy bodies in sporadic Parkinson's disease",

abstract = "Parkinson's disease (PD) is a neurodegnerative disorder that is pathologically characterized by the presence of Lewy bodies in the brain. We show that Lewy bodies in PD are strongly immunoreactive for torsinA, the protein product of the DYT1 gene, which is associated with primary generalized dystonia. In the substantia nigra, torsinA immunoreactivity is localized to the periphery of Lewy bodies, whereas, in cortical Lewy bodies it is uniformly distributed. The significance of this finding is unknown, but may implicate torsinA in neuronal dysfunction that occurs in PD as well as in primary dystonia. (C) 2000 Elsevier Science B.V.",

keywords = "Lewy bodies, Parkinson's disease, Torsion dystonia, α-synuclein",

author = "P. Shashidharan and Good, {P. F.} and A. Hsu and Perl, {D. P.} and Brin, {M. F.} and Olanow, {C. W.}",

note = "Funding Information: This project was supported by the Bachmann–Strauss Dystonia & Parkinson Foundation Inc., New York (P.S.). The authors are grateful to Dr. Ruth Walker for reviewing the manuscript.",

year = "2000",

month = sep,

day = "22",

doi = "10.1016/S0006-8993(00)02702-5",

language = "English",

volume = "877",

pages = "379--381",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - TorsinA accumulation in Lewy bodies in sporadic Parkinson's disease

AU - Shashidharan, P.

AU - Good, P. F.

AU - Hsu, A.

AU - Perl, D. P.

AU - Brin, M. F.

AU - Olanow, C. W.

N1 - Funding Information: This project was supported by the Bachmann–Strauss Dystonia & Parkinson Foundation Inc., New York (P.S.). The authors are grateful to Dr. Ruth Walker for reviewing the manuscript.

PY - 2000/9/22

Y1 - 2000/9/22

N2 - Parkinson's disease (PD) is a neurodegnerative disorder that is pathologically characterized by the presence of Lewy bodies in the brain. We show that Lewy bodies in PD are strongly immunoreactive for torsinA, the protein product of the DYT1 gene, which is associated with primary generalized dystonia. In the substantia nigra, torsinA immunoreactivity is localized to the periphery of Lewy bodies, whereas, in cortical Lewy bodies it is uniformly distributed. The significance of this finding is unknown, but may implicate torsinA in neuronal dysfunction that occurs in PD as well as in primary dystonia. (C) 2000 Elsevier Science B.V.

AB - Parkinson's disease (PD) is a neurodegnerative disorder that is pathologically characterized by the presence of Lewy bodies in the brain. We show that Lewy bodies in PD are strongly immunoreactive for torsinA, the protein product of the DYT1 gene, which is associated with primary generalized dystonia. In the substantia nigra, torsinA immunoreactivity is localized to the periphery of Lewy bodies, whereas, in cortical Lewy bodies it is uniformly distributed. The significance of this finding is unknown, but may implicate torsinA in neuronal dysfunction that occurs in PD as well as in primary dystonia. (C) 2000 Elsevier Science B.V.

KW - Lewy bodies

KW - Parkinson's disease

KW - Torsion dystonia

KW - α-synuclein

UR - http://www.scopus.com/inward/record.url?scp=0034703336&partnerID=8YFLogxK

U2 - 10.1016/S0006-8993(00)02702-5

DO - 10.1016/S0006-8993(00)02702-5

M3 - Article

C2 - 10986355

AN - SCOPUS:0034703336

SN - 0006-8993

VL - 877

SP - 379

EP - 381

JO - Brain Research

JF - Brain Research

IS - 2

ER -

TorsinA accumulation in Lewy bodies in sporadic Parkinson's disease

Abstract

Keywords

Access to Document

Fingerprint

Cite this