Topical cantharidin in the management of molluscum contagiosum: Preliminary Assessment of an Ether-free, Pharmaceutical-grade Formulation

James Q. Del Rosso, Leon Kircik

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Topicalapplicationofcantharidin,avesicantthat isnaturallyderivedfromtheblisterbeetle,hasa longtrackrecordofbeingusedtotreatprimarily cutaneousmolluscumcontagiosumandverrucae. AlthoughnotapprovedbytheUnitedStates FoodandDrugAdministration,cantharidinhas beenavailablethroughavarietyofcompounding sourceswithout standardizationofmanufacturing, formulation,ormethodofapplication. Randomized,controlledstudiesassessingsafety andefficacyoftopicalcantharidinarelimited, todate,withthemajorityofpublishedevidence gleanedfromcollectiveclinicalexperience.A recentPhaseIIpilotstudyevaluatingaspecific formulationofcantharidin0.7%solution[w/v] (VP-102)hasdemonstratedpromisingefficacyand safetyresults,withadditionalstudiesforthcoming, includingthedesignateduseofapatented applicationdevicethatcontainsthesolution.

Original languageEnglish
Pages (from-to)27-30
Number of pages4
JournalJournal of Clinical and Aesthetic Dermatology
Volume12
Issue number2
StatePublished - 2019

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