Topical Calcineurin Inhibitors

Patricia Tinio, Mark G. Lebwohl

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The calcineurin inhibitors were developed as an alternative to topical and systemic glucocorticoids for immunosuppressive therapy. They were primarily used for the prevention of organ transplant rejection. These drugs include cyclosporin and the macrolides tacrolimus (FK 506) and, most recently, pimecrolimus (SDZ ASM 981), which are known to modify immune function by inhibition of calcineurin-dependent reactions critical in the production of inflammatory cytokines (1).

Original languageEnglish
Title of host publicationMild-to-Moderate
Subtitle of host publicationPsoriasis
PublisherCRC Press
Number of pages9
ISBN (Electronic)9781420019315
ISBN (Print)9780849337239
StatePublished - 1 Jan 2006


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