TY - CHAP
T1 - Tools for Characterizing Proteins
T2 - Circular Variance, Mutual Proximity, Chameleon Sequences, and Subsequence Propensities
AU - Mezei, Mihaly
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2022
Y1 - 2022
N2 - For the characterization of various aspects of protein structures, four useful concepts are discussed: chameleon sequences, circular variance, mutual proximity, and a subsequence-based foldability score. These concepts were used in estimating foldability of globular, intrinsically disordered and fold-switching proteins, properties of protein–protein interfaces, quantifying sphericity, helping to improve protein–protein docking scores, and estimating the effect of mutations on stability. A conjecture about the Achilles’ heel of proteins is presented as well.
AB - For the characterization of various aspects of protein structures, four useful concepts are discussed: chameleon sequences, circular variance, mutual proximity, and a subsequence-based foldability score. These concepts were used in estimating foldability of globular, intrinsically disordered and fold-switching proteins, properties of protein–protein interfaces, quantifying sphericity, helping to improve protein–protein docking scores, and estimating the effect of mutations on stability. A conjecture about the Achilles’ heel of proteins is presented as well.
KW - Amino acid propensity
KW - Chameleon sequence
KW - Circular variance
KW - Foldability score
KW - Mutual proximity
UR - http://www.scopus.com/inward/record.url?scp=85126994879&partnerID=8YFLogxK
U2 - 10.1007/978-1-0716-1855-4_2
DO - 10.1007/978-1-0716-1855-4_2
M3 - Chapter
C2 - 35298807
AN - SCOPUS:85126994879
T3 - Methods in Molecular Biology
SP - 39
EP - 61
BT - Methods in Molecular Biology
PB - Humana Press Inc.
ER -