Toll-like receptor 1 variation increases the risk of transplant-related mortality in hematologic malignancies

Kaori Uchino; Shohei Mizuno; Motonori Mizutani; Tomohiro Horio; Ichiro Hanamura; J. Luis Espinoza; Keitaro Matsuo; Makoto Onizuka; Koichi Kashiwase; Yasuo Morishima; Takahiro Fukuda; Yoshihisa Kodera; Noriko Doki; Koichi Miyamura; Takehiko Mori Takehiko Mori; Akiyoshi Takami

doi:10.1016/j.trim.2016.06.002

Toll-like receptor 1 variation increases the risk of transplant-related mortality in hematologic malignancies

Kaori Uchino, Shohei Mizuno, Motonori Mizutani, Tomohiro Horio, Ichiro Hanamura, J. Luis Espinoza, Keitaro Matsuo, Makoto Onizuka, Koichi Kashiwase, Yasuo Morishima, Takahiro Fukuda, Yoshihisa Kodera, Noriko Doki, Koichi Miyamura, Takehiko Mori Takehiko Mori, Akiyoshi Takami

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Toll-like receptor 1 (TLR1) genetic variant (rs5743551, − 7202A > G) has been reported to be associated with susceptibility to various infectious diseases. We retrospectively examined the impact of TLR1 variation on transplant outcomes in a cohort of 320 patients who underwent unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies. A multivariate analysis showed that the G/G genotype in the recipients and the donors was associated with a significantly lower 3-year transplant-related mortality (TRM). The recipient G/G genotype also resulted in a better 3-year progression-free survival. This study suggests that the recipient and donor TLR1 G/G genotypes are comparably associated with a reduced risk of death that was not related to relapse. Thus, TLR1 genotyping may be useful for selecting the donor, managing patients in a risk-adapted manner, and creating therapeutic strategies to prevent complications after hematopoietic stem cell transplantation.

Original language	English
Pages (from-to)	60-66
Number of pages	7
Journal	Transplant Immunology
Volume	38
DOIs	https://doi.org/10.1016/j.trim.2016.06.002
State	Published - 1 Sep 2016
Externally published	Yes

Keywords

Bone marrow transplantation
Single nucleotide variation
TLR1
Unrelated donor

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10.1016/j.trim.2016.06.002

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Uchino, K., Mizuno, S., Mizutani, M., Horio, T., Hanamura, I., Espinoza, J. L., Matsuo, K., Onizuka, M., Kashiwase, K., Morishima, Y., Fukuda, T., Kodera, Y., Doki, N., Miyamura, K., Mori, T. M. T., & Takami, A. (2016). Toll-like receptor 1 variation increases the risk of transplant-related mortality in hematologic malignancies. Transplant Immunology, 38, 60-66. https://doi.org/10.1016/j.trim.2016.06.002

@article{d4d6b053d4954994950fe57899110895,

title = "Toll-like receptor 1 variation increases the risk of transplant-related mortality in hematologic malignancies",

abstract = "Toll-like receptor 1 (TLR1) genetic variant (rs5743551, − 7202A > G) has been reported to be associated with susceptibility to various infectious diseases. We retrospectively examined the impact of TLR1 variation on transplant outcomes in a cohort of 320 patients who underwent unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies. A multivariate analysis showed that the G/G genotype in the recipients and the donors was associated with a significantly lower 3-year transplant-related mortality (TRM). The recipient G/G genotype also resulted in a better 3-year progression-free survival. This study suggests that the recipient and donor TLR1 G/G genotypes are comparably associated with a reduced risk of death that was not related to relapse. Thus, TLR1 genotyping may be useful for selecting the donor, managing patients in a risk-adapted manner, and creating therapeutic strategies to prevent complications after hematopoietic stem cell transplantation.",

keywords = "Bone marrow transplantation, Single nucleotide variation, TLR1, Unrelated donor",

author = "Kaori Uchino and Shohei Mizuno and Motonori Mizutani and Tomohiro Horio and Ichiro Hanamura and Espinoza, \{J. Luis\} and Keitaro Matsuo and Makoto Onizuka and Koichi Kashiwase and Yasuo Morishima and Takahiro Fukuda and Yoshihisa Kodera and Noriko Doki and Koichi Miyamura and Mori, \{Takehiko Mori Takehiko\} and Akiyoshi Takami",

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year = "2016",

month = sep,

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doi = "10.1016/j.trim.2016.06.002",

language = "English",

volume = "38",

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Uchino, K, Mizuno, S, Mizutani, M, Horio, T, Hanamura, I, Espinoza, JL, Matsuo, K, Onizuka, M, Kashiwase, K, Morishima, Y, Fukuda, T, Kodera, Y, Doki, N, Miyamura, K, Mori, TMT & Takami, A 2016, 'Toll-like receptor 1 variation increases the risk of transplant-related mortality in hematologic malignancies', Transplant Immunology, vol. 38, pp. 60-66. https://doi.org/10.1016/j.trim.2016.06.002

TY - JOUR

T1 - Toll-like receptor 1 variation increases the risk of transplant-related mortality in hematologic malignancies

AU - Uchino, Kaori

AU - Mizuno, Shohei

AU - Mizutani, Motonori

AU - Horio, Tomohiro

AU - Hanamura, Ichiro

AU - Espinoza, J. Luis

AU - Matsuo, Keitaro

AU - Onizuka, Makoto

AU - Kashiwase, Koichi

AU - Morishima, Yasuo

AU - Fukuda, Takahiro

AU - Kodera, Yoshihisa

AU - Doki, Noriko

AU - Miyamura, Koichi

AU - Mori, Takehiko Mori Takehiko

AU - Takami, Akiyoshi

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Toll-like receptor 1 (TLR1) genetic variant (rs5743551, − 7202A > G) has been reported to be associated with susceptibility to various infectious diseases. We retrospectively examined the impact of TLR1 variation on transplant outcomes in a cohort of 320 patients who underwent unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies. A multivariate analysis showed that the G/G genotype in the recipients and the donors was associated with a significantly lower 3-year transplant-related mortality (TRM). The recipient G/G genotype also resulted in a better 3-year progression-free survival. This study suggests that the recipient and donor TLR1 G/G genotypes are comparably associated with a reduced risk of death that was not related to relapse. Thus, TLR1 genotyping may be useful for selecting the donor, managing patients in a risk-adapted manner, and creating therapeutic strategies to prevent complications after hematopoietic stem cell transplantation.

AB - Toll-like receptor 1 (TLR1) genetic variant (rs5743551, − 7202A > G) has been reported to be associated with susceptibility to various infectious diseases. We retrospectively examined the impact of TLR1 variation on transplant outcomes in a cohort of 320 patients who underwent unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies. A multivariate analysis showed that the G/G genotype in the recipients and the donors was associated with a significantly lower 3-year transplant-related mortality (TRM). The recipient G/G genotype also resulted in a better 3-year progression-free survival. This study suggests that the recipient and donor TLR1 G/G genotypes are comparably associated with a reduced risk of death that was not related to relapse. Thus, TLR1 genotyping may be useful for selecting the donor, managing patients in a risk-adapted manner, and creating therapeutic strategies to prevent complications after hematopoietic stem cell transplantation.

KW - Bone marrow transplantation

KW - Single nucleotide variation

KW - TLR1

KW - Unrelated donor

UR - https://www.scopus.com/pages/publications/84987602230

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DO - 10.1016/j.trim.2016.06.002

M3 - Article

C2 - 27369862

AN - SCOPUS:84987602230

SN - 0966-3274

VL - 38

SP - 60

EP - 66

JO - Transplant Immunology

JF - Transplant Immunology

ER -

Toll-like receptor 1 variation increases the risk of transplant-related mortality in hematologic malignancies

Abstract

Keywords

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