TY - JOUR
T1 - Tobacco smoking, alcohol drinking and Hodgkin's lymphoma
T2 - A European multi-centre case-control study (EPILYMPH)
AU - Besson, H.
AU - Brennan, P.
AU - Becker, N.
AU - De Sanjosé, S.
AU - Nieters, A.
AU - Font, R.
AU - Maynadié, M.
AU - Foretova, L.
AU - Cocco, P. L.
AU - Staines, A.
AU - Vornanen, M.
AU - Boffetta, P.
N1 - Funding Information:
Funding institutions: European Commission (SOC 98 201307 05F02 and QLK4-CT-2000–00422), Federal Office for Radiation Protection (StSch4261 and StSch4420), German Research Foundation (4850/161/03) and Fondation de France (1999–008471). Hervé Besson performed the analyses and wrote this paper while receiving a Special Training Award from the Gene–Environment Epidemiology Group at the International Agency for Research on Cancer. We thank as well Aurélie Meunier from the International Agency for Research on Cancer for managing the international database.
PY - 2006/8/7
Y1 - 2006/8/7
N2 - We analysed the effects of tobacco and alcohol in the aetiology of Hodgkin's lymphoma (HL), based on 340 cases and 2465 controls enrolled in Spain, France, Italy, Germany, Ireland and Czech Republic, between 1998 and 2004. Current smokers showed a significantly increased odds ratio (OR) of HL of 1.39 (95% confidence interval (CI)=1.04-1.87). Analyses were also conducted separately for subjects younger than 35 years (179 cases) and for older subjects (161 cases). For subjects below age 35, no association was observed between tobacco and HL, whereas for older subjects, ever-smokers experienced a doubled risk of HL as compared to never smokers and the OR of HL for current smoking was 2.35 (95% CI=1.52-3.61), with suggestion of a dose-response relationship. A protective effect of alcohol was observed in both age groups. The OR for ever-regular drinking was 0.58 (95% CI=0.38-0.89) for younger subjects and 0.50 (95% CI=0.34-0.74) for older subjects. There was no evidence of interaction between tobacco and alcohol. Our results are consistent with previous studies, suggesting a protective effect of alcohol on HL. An effect of tobacco was suggested for HL occurring in middle and late age, although this finding might have occurred by chance.
AB - We analysed the effects of tobacco and alcohol in the aetiology of Hodgkin's lymphoma (HL), based on 340 cases and 2465 controls enrolled in Spain, France, Italy, Germany, Ireland and Czech Republic, between 1998 and 2004. Current smokers showed a significantly increased odds ratio (OR) of HL of 1.39 (95% confidence interval (CI)=1.04-1.87). Analyses were also conducted separately for subjects younger than 35 years (179 cases) and for older subjects (161 cases). For subjects below age 35, no association was observed between tobacco and HL, whereas for older subjects, ever-smokers experienced a doubled risk of HL as compared to never smokers and the OR of HL for current smoking was 2.35 (95% CI=1.52-3.61), with suggestion of a dose-response relationship. A protective effect of alcohol was observed in both age groups. The OR for ever-regular drinking was 0.58 (95% CI=0.38-0.89) for younger subjects and 0.50 (95% CI=0.34-0.74) for older subjects. There was no evidence of interaction between tobacco and alcohol. Our results are consistent with previous studies, suggesting a protective effect of alcohol on HL. An effect of tobacco was suggested for HL occurring in middle and late age, although this finding might have occurred by chance.
KW - Alcohol
KW - Europe
KW - Hodgkin's lymphoma
KW - Tobacco
UR - https://www.scopus.com/pages/publications/33746909062
U2 - 10.1038/sj.bjc.6603229
DO - 10.1038/sj.bjc.6603229
M3 - Article
C2 - 16819547
AN - SCOPUS:33746909062
SN - 0007-0920
VL - 95
SP - 378
EP - 384
JO - British Journal of Cancer
JF - British Journal of Cancer
IS - 3
ER -