To Include or Exclude? That Is the Question for Clinical Researchers Investigating in the Current Opioid Epidemic

Jason K. Panchamia; Adam W. Amundson; Jashvant Poeran; Ngoc Tram V. Nguyen; Sandra L. Kopp; Rebecca L. Johnson

doi:10.1213/ANE.0000000000004090

To Include or Exclude? That Is the Question for Clinical Researchers Investigating in the Current Opioid Epidemic

Jason K. Panchamia
, Adam W. Amundson
, Jashvant Poeran
, Ngoc Tram V. Nguyen
, Sandra L. Kopp
, Rebecca L. Johnson

Research output: Contribution to journal › Article › peer-review

Abstract

The opioid epidemic has adversely affected patient recruitment and consequently prolonged time until study completion for our recent randomized controlled trials. Opioid-tolerant surgical patients create a dilemma between internal and external validity in regional anesthesia-related randomized controlled trials. We have highlighted several problems performing experimental trial research in the opioid epidemic while also detailing potential solutions.

Original language	English
Pages (from-to)	1045-1050
Number of pages	6
Journal	Anesthesia and Analgesia
Volume	128
Issue number	5
DOIs	https://doi.org/10.1213/ANE.0000000000004090
State	Published - 2019
Externally published	Yes

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abstract = "The opioid epidemic has adversely affected patient recruitment and consequently prolonged time until study completion for our recent randomized controlled trials. Opioid-tolerant surgical patients create a dilemma between internal and external validity in regional anesthesia-related randomized controlled trials. We have highlighted several problems performing experimental trial research in the opioid epidemic while also detailing potential solutions.",

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AU - Kopp, Sandra L.

AU - Johnson, Rebecca L.

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AB - The opioid epidemic has adversely affected patient recruitment and consequently prolonged time until study completion for our recent randomized controlled trials. Opioid-tolerant surgical patients create a dilemma between internal and external validity in regional anesthesia-related randomized controlled trials. We have highlighted several problems performing experimental trial research in the opioid epidemic while also detailing potential solutions.

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To Include or Exclude? That Is the Question for Clinical Researchers Investigating in the Current Opioid Epidemic

Abstract

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