To B or Not to B? B-cells and graft rejection

Valeriya Zarkhin, Li Li, Minnie Sarwal

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations


There is increasing evidence that various maturational stages of B-cells infiltrate various solid organ transplants undergoing acute rejection. The presence of immature CD20 and mature CD138 plasma cells associate with more aggressive and steroid-recalcitrant graft rejection and portend poor graft outcomes. Though associative, the causal role of B-cells in graft rejection remains to be better understood. This review discusses the possible roles of B-cells in graft rejection, whether involved as antigen presenting, as indirect effector, or antibody producing cells.

Original languageEnglish
Pages (from-to)1705-1714
Number of pages10
Issue number12
StatePublished - 27 Jun 2008
Externally publishedYes


  • Acute rejection
  • B-cells
  • Graft survival
  • Transplantation


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