Tissue specificity in the expression of friend erythroleukemic virus sequences in infected mouse tissues

Michael E. Joesten; Moira E. Royston; Beatriz G.T. Pogo

doi:10.1016/0145-2126(89)90017-9

Tissue specificity in the expression of friend erythroleukemic virus sequences in infected mouse tissues

Michael E. Joesten
, Moira E. Royston
, Beatriz G.T. Pogo

Research output: Contribution to journal › Article › peer-review

Abstract

The SQA cell line produces Friend leukemia virus that remains leukemogenic after serial passages in vitro. The state of the provirus and its expression were investigated in newborn and adult mouse tissues, using probes specific for ecotropic and xenotropic sequences. Genomic ecotropic and xenotropic sequences were similar in size in spleen and liver of infected and control animals but appear amplified in infected tissues. Expression of these sequences however differed. Several species of xenotropic and ecotropic-specific RNAs were detected in infected spleens, in SQA cells and in the liver of newborn infected animals but were absent in infected adult liver and control tissues. These results suggest that activation and expression of ecotropic and xenotropic endogenous sequences may play a role in pathogenesis of the disease.

Original language	English
Pages (from-to)	233-239
Number of pages	7
Journal	Leukemia Research
Volume	13
Issue number	3
DOIs	https://doi.org/10.1016/0145-2126(89)90017-9
State	Published - 1989

Keywords

F-MuLv expression
MCF expression
endogenous proviral activation
murine erythroleukemia

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10.1016/0145-2126(89)90017-9

Cite this

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title = "Tissue specificity in the expression of friend erythroleukemic virus sequences in infected mouse tissues",

abstract = "The SQA cell line produces Friend leukemia virus that remains leukemogenic after serial passages in vitro. The state of the provirus and its expression were investigated in newborn and adult mouse tissues, using probes specific for ecotropic and xenotropic sequences. Genomic ecotropic and xenotropic sequences were similar in size in spleen and liver of infected and control animals but appear amplified in infected tissues. Expression of these sequences however differed. Several species of xenotropic and ecotropic-specific RNAs were detected in infected spleens, in SQA cells and in the liver of newborn infected animals but were absent in infected adult liver and control tissues. These results suggest that activation and expression of ecotropic and xenotropic endogenous sequences may play a role in pathogenesis of the disease.",

keywords = "F-MuLv expression, MCF expression, endogenous proviral activation, murine erythroleukemia",

author = "Joesten, \{Michael E.\} and Royston, \{Moira E.\} and Pogo, \{Beatriz G.T.\}",

note = "Funding Information: Acknowledgements--This work was supported by grants CA 10000 and CA 13047 from the National Institutes of Health and the Chemotherapy Foundation.",

year = "1989",

doi = "10.1016/0145-2126(89)90017-9",

language = "English",

volume = "13",

pages = "233--239",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Ltd.",

number = "3",

}

TY - JOUR

T1 - Tissue specificity in the expression of friend erythroleukemic virus sequences in infected mouse tissues

AU - Joesten, Michael E.

AU - Royston, Moira E.

AU - Pogo, Beatriz G.T.

N1 - Funding Information: Acknowledgements--This work was supported by grants CA 10000 and CA 13047 from the National Institutes of Health and the Chemotherapy Foundation.

PY - 1989

Y1 - 1989

N2 - The SQA cell line produces Friend leukemia virus that remains leukemogenic after serial passages in vitro. The state of the provirus and its expression were investigated in newborn and adult mouse tissues, using probes specific for ecotropic and xenotropic sequences. Genomic ecotropic and xenotropic sequences were similar in size in spleen and liver of infected and control animals but appear amplified in infected tissues. Expression of these sequences however differed. Several species of xenotropic and ecotropic-specific RNAs were detected in infected spleens, in SQA cells and in the liver of newborn infected animals but were absent in infected adult liver and control tissues. These results suggest that activation and expression of ecotropic and xenotropic endogenous sequences may play a role in pathogenesis of the disease.

AB - The SQA cell line produces Friend leukemia virus that remains leukemogenic after serial passages in vitro. The state of the provirus and its expression were investigated in newborn and adult mouse tissues, using probes specific for ecotropic and xenotropic sequences. Genomic ecotropic and xenotropic sequences were similar in size in spleen and liver of infected and control animals but appear amplified in infected tissues. Expression of these sequences however differed. Several species of xenotropic and ecotropic-specific RNAs were detected in infected spleens, in SQA cells and in the liver of newborn infected animals but were absent in infected adult liver and control tissues. These results suggest that activation and expression of ecotropic and xenotropic endogenous sequences may play a role in pathogenesis of the disease.

KW - F-MuLv expression

KW - MCF expression

KW - endogenous proviral activation

KW - murine erythroleukemia

UR - https://www.scopus.com/pages/publications/0024593181

U2 - 10.1016/0145-2126(89)90017-9

DO - 10.1016/0145-2126(89)90017-9

M3 - Article

C2 - 2709877

AN - SCOPUS:0024593181

SN - 0145-2126

VL - 13

SP - 233

EP - 239

JO - Leukemia Research

JF - Leukemia Research

IS - 3

ER -

Tissue specificity in the expression of friend erythroleukemic virus sequences in infected mouse tissues

Abstract

Keywords

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