Tissue-specific sex differences in galanin-like immunoreactivity and galanin mRNA during development in the rat

Steven M. Gabriel; Lee M. Kaplan; Joseph B. Martin; James I. Koenig

doi:10.1016/0196-9781(89)90045-4

Tissue-specific sex differences in galanin-like immunoreactivity and galanin mRNA during development in the rat

Steven M. Gabriel
, Lee M. Kaplan
, Joseph B. Martin
, James I. Koenig

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

Galanin-like immunoreactivity (Gal-LI), as determined by radioimmunoassay, was detectable in the brain and gastrointestinal tract by day 15 of gestation. Concentrations of Gal-LI increased after birth in the hypothalamus but decreased in the stomach and duodenum. A sex difference in Gal-LI concentrations appeared during puberty in the median eminence, neurointermediate lobe, and the anterior pituitary (AP), where females had higher Gal-LI concentrations compared to males. This difference was most pronounced in the AP; adult females had up to 4-fold greater Gal-LI concentrations and 5-fold more abundant rGal-specific mRNA compared to males.

Original language	English
Pages (from-to)	369-374
Number of pages	6
Journal	Peptides
Volume	10
Issue number	2
DOIs	https://doi.org/10.1016/0196-9781(89)90045-4
State	Published - 1989
Externally published	Yes

Keywords

Anterior pituitary
Estrogens
Galanin
Gonadal steroids
Hypothalamus
Sex dimorphism
Sexual differentiation

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10.1016/0196-9781(89)90045-4

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@article{3290794ccf024a079c161f9c5c394d40,

title = "Tissue-specific sex differences in galanin-like immunoreactivity and galanin mRNA during development in the rat",

abstract = "Galanin-like immunoreactivity (Gal-LI), as determined by radioimmunoassay, was detectable in the brain and gastrointestinal tract by day 15 of gestation. Concentrations of Gal-LI increased after birth in the hypothalamus but decreased in the stomach and duodenum. A sex difference in Gal-LI concentrations appeared during puberty in the median eminence, neurointermediate lobe, and the anterior pituitary (AP), where females had higher Gal-LI concentrations compared to males. This difference was most pronounced in the AP; adult females had up to 4-fold greater Gal-LI concentrations and 5-fold more abundant rGal-specific mRNA compared to males.",

keywords = "Anterior pituitary, Estrogens, Galanin, Gonadal steroids, Hypothalamus, Sex dimorphism, Sexual differentiation",

author = "Gabriel, \{Steven M.\} and Kaplan, \{Lee M.\} and Martin, \{Joseph B.\} and Koenig, \{James I.\}",

note = "Funding Information: The authors thank Ms. Carol Milbury for her excellent technical assistance. A preliminary report of this work was presented at the 70th annual Endocrine Society Meeting, New Orleans, LA, June 1988. This work was supported by NIH grants DK07561 (S.M.G.), DK39251 (J.I.K.) and AM26252 (J.B.M.), and the American Gastroenterological Association (L.M.K.).",

year = "1989",

doi = "10.1016/0196-9781(89)90045-4",

language = "English",

volume = "10",

pages = "369--374",

journal = "Peptides",

issn = "0196-9781",

publisher = "Elsevier Inc.",

number = "2",

}

TY - JOUR

T1 - Tissue-specific sex differences in galanin-like immunoreactivity and galanin mRNA during development in the rat

AU - Gabriel, Steven M.

AU - Kaplan, Lee M.

AU - Martin, Joseph B.

AU - Koenig, James I.

N1 - Funding Information: The authors thank Ms. Carol Milbury for her excellent technical assistance. A preliminary report of this work was presented at the 70th annual Endocrine Society Meeting, New Orleans, LA, June 1988. This work was supported by NIH grants DK07561 (S.M.G.), DK39251 (J.I.K.) and AM26252 (J.B.M.), and the American Gastroenterological Association (L.M.K.).

PY - 1989

Y1 - 1989

N2 - Galanin-like immunoreactivity (Gal-LI), as determined by radioimmunoassay, was detectable in the brain and gastrointestinal tract by day 15 of gestation. Concentrations of Gal-LI increased after birth in the hypothalamus but decreased in the stomach and duodenum. A sex difference in Gal-LI concentrations appeared during puberty in the median eminence, neurointermediate lobe, and the anterior pituitary (AP), where females had higher Gal-LI concentrations compared to males. This difference was most pronounced in the AP; adult females had up to 4-fold greater Gal-LI concentrations and 5-fold more abundant rGal-specific mRNA compared to males.

AB - Galanin-like immunoreactivity (Gal-LI), as determined by radioimmunoassay, was detectable in the brain and gastrointestinal tract by day 15 of gestation. Concentrations of Gal-LI increased after birth in the hypothalamus but decreased in the stomach and duodenum. A sex difference in Gal-LI concentrations appeared during puberty in the median eminence, neurointermediate lobe, and the anterior pituitary (AP), where females had higher Gal-LI concentrations compared to males. This difference was most pronounced in the AP; adult females had up to 4-fold greater Gal-LI concentrations and 5-fold more abundant rGal-specific mRNA compared to males.

KW - Anterior pituitary

KW - Estrogens

KW - Galanin

KW - Gonadal steroids

KW - Hypothalamus

KW - Sex dimorphism

KW - Sexual differentiation

UR - https://www.scopus.com/pages/publications/0024318848

U2 - 10.1016/0196-9781(89)90045-4

DO - 10.1016/0196-9781(89)90045-4

M3 - Article

C2 - 2474154

AN - SCOPUS:0024318848

SN - 0196-9781

VL - 10

SP - 369

EP - 374

JO - Peptides

JF - Peptides

IS - 2

ER -

Tissue-specific sex differences in galanin-like immunoreactivity and galanin mRNA during development in the rat

Abstract

Keywords

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