Tissue-specific sex differences in galanin-like immunoreactivity and galanin mRNA during development in the rat

Steven M. Gabriel, Lee M. Kaplan, Joseph B. Martin, James I. Koenig

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

Galanin-like immunoreactivity (Gal-LI), as determined by radioimmunoassay, was detectable in the brain and gastrointestinal tract by day 15 of gestation. Concentrations of Gal-LI increased after birth in the hypothalamus but decreased in the stomach and duodenum. A sex difference in Gal-LI concentrations appeared during puberty in the median eminence, neurointermediate lobe, and the anterior pituitary (AP), where females had higher Gal-LI concentrations compared to males. This difference was most pronounced in the AP; adult females had up to 4-fold greater Gal-LI concentrations and 5-fold more abundant rGal-specific mRNA compared to males.

Original languageEnglish
Pages (from-to)369-374
Number of pages6
JournalPeptides
Volume10
Issue number2
DOIs
StatePublished - 1989
Externally publishedYes

Keywords

  • Anterior pituitary
  • Estrogens
  • Galanin
  • Gonadal steroids
  • Hypothalamus
  • Sex dimorphism
  • Sexual differentiation

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