Tissue-mediated control of immunopathology in coeliac disease

Bana Jabri, Ludvig M. Sollid

Research output: Contribution to journalReview articlepeer-review

260 Scopus citations

Abstract

Coeliac disease is an inflammatory disorder with autoimmune features that is characterized by destruction of the intestinal epithelium and remodelling of the intestinal mucosa following the ingestion of dietary gluten. A common feature of coeliac disease and many organ-specific autoimmune diseases is a central role for T cells in causing tissue destruction. In this Review, we discuss the emerging hypothesis that, in coeliac disease, intestinal tissue inflammation induced either by infectious agents or by gluten is crucial for activating T cells and eliciting their tissue-destructive effector functions.

Original languageEnglish
Pages (from-to)858-870
Number of pages13
JournalNature Reviews Immunology
Volume9
Issue number12
DOIs
StatePublished - Dec 2009
Externally publishedYes

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