Abstract
Tissue engineering is a rapidly growing field at the junction between biological and physical sciences. Tissue creation in vitro and in vivo holds the potential to revolutionize modern medicine by providing therapies for a vast array of diseases. Diseases that affect the myocardium, coronary vasculature, and heart valves, or congenital cardiac defects, are targets for tissue engineering strategies. Of these, the creation of replacement myocardium poses the greatest challenge because currently there are few treatment options for a failing heart [1]. This chapter will focus on the principles of tissue engineering, candidate cells that can be used in construct creation, and biomaterial options for three dimensional scaffolding as they specifically relate to engineered myocardial substitutes. A brief discussion on engineered heart valve and vascular substitutes will follow.
| Original language | English |
|---|---|
| Title of host publication | Fundamentals of Tissue Engineering and Regenerative Medicine |
| Publisher | Springer Berlin Heidelberg |
| Pages | 887-911 |
| Number of pages | 25 |
| ISBN (Print) | 9783540777540 |
| DOIs | |
| State | Published - 2009 |
| Externally published | Yes |