Tissue Destruction by Neutrophils

Mark Levine; Philip W. Washko; Timo Sorsa; Herkko Saari; Yrjö T. Konttinen; Veli Jukka Vitto; Seppo Lindy; Alfred I. Tauber; Stephen J. Weiss; Vivek Y. Reddy

doi:10.1056/NEJM198908033210513

Tissue Destruction by Neutrophils

Mark Levine, Philip W. Washko, Timo Sorsa, Herkko Saari, Yrjö T. Konttinen, Veli Jukka Vitto, Seppo Lindy, Alfred I. Tauber, Stephen J. Weiss, Vivek Y. Reddy

Research output: Contribution to journal › Letter › peer-review

33 Scopus citations

Abstract

To the Editor: In the excellent article by Weiss on tissue destruction by neutrophils (Feb. 9 issue),¹ there is an implicit assumption that neutrophils lack endogenous reducing substances that could quench intracellular or extracellular oxidants. We would therefore like to emphasize that ascorbic acid is present in human neutrophils, in concentrations 20 to 30 times higher than in plasma.² Although the function of ascorbic acid in neutrophils is unknown, it has been proposed that it quenches free radicals,³ either within or perhaps outside neutrophils. However, before this or other functions of neutrophil ascorbic acid can be addressed, it is of…

Original language	English
Pages (from-to)	327-329
Number of pages	3
Journal	New England Journal of Medicine
Volume	321
Issue number	5
DOIs	https://doi.org/10.1056/NEJM198908033210513
State	Published - 3 Aug 1989
Externally published	Yes

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title = "Tissue Destruction by Neutrophils",

abstract = "To the Editor: In the excellent article by Weiss on tissue destruction by neutrophils (Feb. 9 issue),1 there is an implicit assumption that neutrophils lack endogenous reducing substances that could quench intracellular or extracellular oxidants. We would therefore like to emphasize that ascorbic acid is present in human neutrophils, in concentrations 20 to 30 times higher than in plasma.2 Although the function of ascorbic acid in neutrophils is unknown, it has been proposed that it quenches free radicals,3 either within or perhaps outside neutrophils. However, before this or other functions of neutrophil ascorbic acid can be addressed, it is of…",

author = "Mark Levine and Washko, {Philip W.} and Timo Sorsa and Herkko Saari and Konttinen, {Yrj{\"o} T.} and Vitto, {Veli Jukka} and Seppo Lindy and Tauber, {Alfred I.} and Weiss, {Stephen J.} and Reddy, {Vivek Y.}",

year = "1989",

month = aug,

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doi = "10.1056/NEJM198908033210513",

language = "English",

volume = "321",

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TY - JOUR

T1 - Tissue Destruction by Neutrophils

AU - Levine, Mark

AU - Washko, Philip W.

AU - Sorsa, Timo

AU - Saari, Herkko

AU - Konttinen, Yrjö T.

AU - Vitto, Veli Jukka

AU - Lindy, Seppo

AU - Tauber, Alfred I.

AU - Weiss, Stephen J.

AU - Reddy, Vivek Y.

PY - 1989/8/3

Y1 - 1989/8/3

N2 - To the Editor: In the excellent article by Weiss on tissue destruction by neutrophils (Feb. 9 issue),1 there is an implicit assumption that neutrophils lack endogenous reducing substances that could quench intracellular or extracellular oxidants. We would therefore like to emphasize that ascorbic acid is present in human neutrophils, in concentrations 20 to 30 times higher than in plasma.2 Although the function of ascorbic acid in neutrophils is unknown, it has been proposed that it quenches free radicals,3 either within or perhaps outside neutrophils. However, before this or other functions of neutrophil ascorbic acid can be addressed, it is of…

AB - To the Editor: In the excellent article by Weiss on tissue destruction by neutrophils (Feb. 9 issue),1 there is an implicit assumption that neutrophils lack endogenous reducing substances that could quench intracellular or extracellular oxidants. We would therefore like to emphasize that ascorbic acid is present in human neutrophils, in concentrations 20 to 30 times higher than in plasma.2 Although the function of ascorbic acid in neutrophils is unknown, it has been proposed that it quenches free radicals,3 either within or perhaps outside neutrophils. However, before this or other functions of neutrophil ascorbic acid can be addressed, it is of…

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U2 - 10.1056/NEJM198908033210513

DO - 10.1056/NEJM198908033210513

M3 - Letter

C2 - 2747775

AN - SCOPUS:0024960660

SN - 0028-4793

VL - 321

SP - 327

EP - 329

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 5

ER -

Tissue Destruction by Neutrophils

Abstract

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