Timing of neuroendocrine responses and effect of m-CPP and fenfluramine plasma levels in OCD

Eric Hollander; Lisa J. Cohen; Concetta DeCaria; Jihad B. Saoud; Dan J. Stein; Thomas B. Cooper; Nazrul N. Islam; Michael R. Liebowitz; Donald F. Klein

doi:10.1016/0006-3223(93)90186-H

Timing of neuroendocrine responses and effect of m-CPP and fenfluramine plasma levels in OCD

Eric Hollander
, Lisa J. Cohen
, Concetta DeCaria
, Jihad B. Saoud
, Dan J. Stein
, Thomas B. Cooper
, Nazrul N. Islam
, Michael R. Liebowitz
, Donald F. Klein

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The present study assesses the timing of and relationship between neuroendocrine response and metabolite blood levels following the partial serotonin (5-HT) agonist m-CPP and the 5-HT releaser/reuptake blocker fenfluramine. Cortisol levels peaked significantly earlier than did prolactin, m-CPP, fenfluramine, or norfenfluramine blood levels by time-to-peak analysis. This earlier cortisol response to both 5-HT agents raises the possibility that peripheral mechanisms may play a role cortisol release. Since peak m-CPP level correlated even more closely to peak prolactin rise than did peak fenfluramine, this suggests that prolactin response to oral m-CPP challenge is useful in assessing 5-HT function.

Original language	English
Pages (from-to)	407-413
Number of pages	7
Journal	Biological Psychiatry
Volume	34
Issue number	6
DOIs	https://doi.org/10.1016/0006-3223(93)90186-H
State	Published - 15 Sep 1993
Externally published	Yes

Keywords

M-CPP
cortisol
fenfluramine
obsessive-compulsive disorder
prolactin
serotonin

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10.1016/0006-3223(93)90186-H

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title = "Timing of neuroendocrine responses and effect of m-CPP and fenfluramine plasma levels in OCD",

abstract = "The present study assesses the timing of and relationship between neuroendocrine response and metabolite blood levels following the partial serotonin (5-HT) agonist m-CPP and the 5-HT releaser/reuptake blocker fenfluramine. Cortisol levels peaked significantly earlier than did prolactin, m-CPP, fenfluramine, or norfenfluramine blood levels by time-to-peak analysis. This earlier cortisol response to both 5-HT agents raises the possibility that peripheral mechanisms may play a role cortisol release. Since peak m-CPP level correlated even more closely to peak prolactin rise than did peak fenfluramine, this suggests that prolactin response to oral m-CPP challenge is useful in assessing 5-HT function.",

keywords = "M-CPP, cortisol, fenfluramine, obsessive-compulsive disorder, prolactin, serotonin",

author = "Eric Hollander and Cohen, \{Lisa J.\} and Concetta DeCaria and Saoud, \{Jihad B.\} and Stein, \{Dan J.\} and Cooper, \{Thomas B.\} and Islam, \{Nazrul N.\} and Liebowitz, \{Michael R.\} and Klein, \{Donald F.\}",

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doi = "10.1016/0006-3223(93)90186-H",

language = "English",

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T1 - Timing of neuroendocrine responses and effect of m-CPP and fenfluramine plasma levels in OCD

AU - Hollander, Eric

AU - Cohen, Lisa J.

AU - DeCaria, Concetta

AU - Saoud, Jihad B.

AU - Stein, Dan J.

AU - Cooper, Thomas B.

AU - Islam, Nazrul N.

AU - Liebowitz, Michael R.

AU - Klein, Donald F.

PY - 1993/9/15

Y1 - 1993/9/15

N2 - The present study assesses the timing of and relationship between neuroendocrine response and metabolite blood levels following the partial serotonin (5-HT) agonist m-CPP and the 5-HT releaser/reuptake blocker fenfluramine. Cortisol levels peaked significantly earlier than did prolactin, m-CPP, fenfluramine, or norfenfluramine blood levels by time-to-peak analysis. This earlier cortisol response to both 5-HT agents raises the possibility that peripheral mechanisms may play a role cortisol release. Since peak m-CPP level correlated even more closely to peak prolactin rise than did peak fenfluramine, this suggests that prolactin response to oral m-CPP challenge is useful in assessing 5-HT function.

AB - The present study assesses the timing of and relationship between neuroendocrine response and metabolite blood levels following the partial serotonin (5-HT) agonist m-CPP and the 5-HT releaser/reuptake blocker fenfluramine. Cortisol levels peaked significantly earlier than did prolactin, m-CPP, fenfluramine, or norfenfluramine blood levels by time-to-peak analysis. This earlier cortisol response to both 5-HT agents raises the possibility that peripheral mechanisms may play a role cortisol release. Since peak m-CPP level correlated even more closely to peak prolactin rise than did peak fenfluramine, this suggests that prolactin response to oral m-CPP challenge is useful in assessing 5-HT function.

KW - M-CPP

KW - cortisol

KW - fenfluramine

KW - obsessive-compulsive disorder

KW - prolactin

KW - serotonin

UR - https://www.scopus.com/pages/publications/0027420971

U2 - 10.1016/0006-3223(93)90186-H

DO - 10.1016/0006-3223(93)90186-H

M3 - Article

C2 - 8218609

AN - SCOPUS:0027420971

SN - 0006-3223

VL - 34

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EP - 413

JO - Biological Psychiatry

JF - Biological Psychiatry

IS - 6

ER -

Timing of neuroendocrine responses and effect of m-CPP and fenfluramine plasma levels in OCD

Abstract

Keywords

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