TY - JOUR
T1 - Time to completed redistribution of thallium-201 in exercise myocardial scintigraphy
T2 - Relationship to the degree of coronary artery stenosis
AU - Gutman, Jack
AU - Berman, Daniel S.
AU - Freeman, Michael
AU - Rozanski, Alan
AU - Maddahi, Jamshid
AU - Waxman, Alan
AU - Swan, H. J.C.
N1 - Funding Information:
From the Division of Cardiology, Department of Medicine, and the Department of Nuclear Medicine, Cedars-Sinai Medical Center; and the Departments of Medicine and Radiology, UCLA School of Medicine. Supported in part by SCOR Grant No. 17651 from the National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md.; and by a research grant from the American Heart Association, Greater Los Angeles Affiliate, Inc. Received for publication Dec. 3, 1982; accepted Jan. 3, 1983. Reprint requests: Daniel S. Berman, M.D., Division of Cardiology, Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA 96948.
PY - 1983/11
Y1 - 1983/11
N2 - The relationship between the severity of coronary artery stenosis and the time to completed redistribution of thallium 201 (Tl-201) defects following maximal exercise was investigated in 59 patients undergoing stress-redistribution Tl-201 scintigraphy, coronary angiography, and contrast ventriculography. Multiple view Tl-201 scintigrams were obtained, beginning 6 minutes (immediately post stress), less than 1 hour (early), 3 to 5 hours (average), and 18 to 24 hours (late) following intravenous Tl-201 injection at peak exercise. Angiographic lesions were grouped into five levels of severity by percent stenosis. In the 107 defects which were seen on the immediate post stress images, early redistribution was noted in 15 (14%) and late redistribution was found in 23 (21%). In addition, there was a correlation (r = 0.56) between the time to completed redistribution and the severity of the coronary artery stenosis (p = 0.001). In comparison to defects with early and average redistribution, the segments contralateral to those with defects showing late redistribution more often had a critical stenosis supplying that segment. The frequency of myocardial infarction on ECG and the number of segments with akinetic and dyskinetic wall motion were less in defects undergoing late rather than no redistribution. Thus the time to completed Tl-201 redistribution following stress appears to be related to the severity of stenosis in the coronary artery supplying the defect. Also, late redistribution is associated with the presence and early redistribution with the absence of a significant stenosis in the coronary artery to the contralateral segment.
AB - The relationship between the severity of coronary artery stenosis and the time to completed redistribution of thallium 201 (Tl-201) defects following maximal exercise was investigated in 59 patients undergoing stress-redistribution Tl-201 scintigraphy, coronary angiography, and contrast ventriculography. Multiple view Tl-201 scintigrams were obtained, beginning 6 minutes (immediately post stress), less than 1 hour (early), 3 to 5 hours (average), and 18 to 24 hours (late) following intravenous Tl-201 injection at peak exercise. Angiographic lesions were grouped into five levels of severity by percent stenosis. In the 107 defects which were seen on the immediate post stress images, early redistribution was noted in 15 (14%) and late redistribution was found in 23 (21%). In addition, there was a correlation (r = 0.56) between the time to completed redistribution and the severity of the coronary artery stenosis (p = 0.001). In comparison to defects with early and average redistribution, the segments contralateral to those with defects showing late redistribution more often had a critical stenosis supplying that segment. The frequency of myocardial infarction on ECG and the number of segments with akinetic and dyskinetic wall motion were less in defects undergoing late rather than no redistribution. Thus the time to completed Tl-201 redistribution following stress appears to be related to the severity of stenosis in the coronary artery supplying the defect. Also, late redistribution is associated with the presence and early redistribution with the absence of a significant stenosis in the coronary artery to the contralateral segment.
UR - http://www.scopus.com/inward/record.url?scp=0021052451&partnerID=8YFLogxK
U2 - 10.1016/0002-8703(83)90642-7
DO - 10.1016/0002-8703(83)90642-7
M3 - Article
C2 - 6637782
AN - SCOPUS:0021052451
SN - 0002-8703
VL - 106
SP - 989
EP - 995
JO - American Heart Journal
JF - American Heart Journal
IS - 5 PART 1
ER -