TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation

Jennifer Hartt Meyers, Sumone Chakravarti, David Schlesinger, Zsolt Illes, Hanspeter Waldner, Sarah E. Umetsu, James Kenny, Xin Xiao Zheng, Dale T. Umetsu, Rosemarie H. DeKruyff, Terry B. Strom, Vijay K. Kuchroo

Research output: Contribution to journalArticlepeer-review

314 Scopus citations

Abstract

The newly identified TIM family of proteins is associated with regulation of T helper type 1 (TH1) and TH2 immune responses. TIM-1 is genetically linked to asthma and is a receptor for hepatitis A virus, but the endogenous ligand of TIM-1 is not known. Here we show that TIM-4, which is expressed by antigen-presenting cells, is the ligand for TIM-1. In vivo administration of either soluble TIM-1-immunoglobulin (TIM-1-Ig) fusion protein or TIM-4-Ig fusion protein resulted in hyperproliferation of T cells, and TIM-4-Ig costimulated T cell proliferation mediated by CD3 and CD28 in vitro. These data suggest that the TIM-1-TIM-4 interaction is involved in regulating T cell proliferation.

Original languageEnglish
Pages (from-to)455-464
Number of pages10
JournalNature Immunology
Volume6
Issue number5
DOIs
StatePublished - 2005
Externally publishedYes

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