Tim-2 regulates T helper type 2 responses and autoimmunity

Sumone Chakravarti, Catherine A. Sabatos, Sheng Xiao, Zsolt Illes, Eugene K. Cha, Raymond A. Sobel, Xin X. Zheng, Terry B. Strom, Vijay K. Kuchroo

Research output: Contribution to journalArticlepeer-review

110 Scopus citations

Abstract

Identification of the T cell immunoglobulin mucin-domain containing (Tim) gene family introduced a new family of cell surface molecules that is involved in the regulation of immune responses. We previously demonstrated that Tim-3 is expressed on terminally differentiated T helper (Th)1 cells, and serves to regulate Th1 immune responses. Here, we describe the identification and function of Tim-2, a novel member of the Tim gene family. In contrast with Tim-3, we demonstrate that Tim-2 is expressed preferentially in differentiated Th2 cells. Blockade of the Tim-2/Tim-2 ligand interaction, by administration of soluble Tim-2 fusion protein (Tim-2 immunoglobulin [Ig]), results in T cell hyperproliferation and the production of Th2 cytokines. Administration of Tim-2 Ig during the induction phase reduces the severity of experimental autoimmune encephalomyelitis, a Th1-mediated autoimmune disease model of multiple sclerosis. We propose that Tim-2, an orthologue of human Tim-1, is critical for the regulation of Th2 responses during autoimmune inflammation. JEM

Original languageEnglish
Pages (from-to)437-444
Number of pages8
JournalJournal of Experimental Medicine
Volume202
Issue number3
DOIs
StatePublished - 1 Aug 2005
Externally publishedYes

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