Tie2-Cre–Induced Inactivation of Non-Nuclear Estrogen Receptor-α Signaling Abrogates Estrogen Protection Against Vascular Injury

Pang Yen Liu, Nobuaki Fukuma, Yukio Hiroi, Akiko Kunita, Hiroyuki Tokiwa, Kazutaka Ueda, Taro Kariya, Genri Numata, Yusuke Adachi, Miyu Tajima, Masayuki Toyoda, Yuxin Li, Kensuke Noma, Mutsuo Harada, Haruhiro Toko, Tetsuo Ushiku, Yoshimitsu Kanai, Eiki Takimoto, James K. Liao, Issei Komuro

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Using the Cre-loxP system, we generated the first mouse model in which estrogen receptor-α non-nuclear signaling was inactivated in endothelial cells. Estrogen protection against mechanical vascular injury was impaired in this model. This result indicates the pivotal role of endothelial estrogen receptor-α non-nuclear signaling in the vasculoprotective effects of estrogen.

Original languageEnglish
Pages (from-to)55-67
Number of pages13
JournalJACC: Basic to Translational Science
Volume8
Issue number1
DOIs
StatePublished - Jan 2023
Externally publishedYes

Keywords

  • endothelial cells
  • estrogen receptor-α
  • non-nuclear signaling
  • tissue-specific regulation

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