"Tie-ing" down the hematopoietic niche

Kateri A. Moore, Ihor R. Lemischka

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

Interaction of hematopoietic stem cells (HSCs) with their particular microenvironment, or niche, is critical for adult hematopoiesis in the bone marrow (BM). Arai et al. (this issue of Cell) demonstrate that HSCs that express the receptor tyrosine kinase Tie2 are quiescent. Ang-1, the ligand for Tie2, enhanced the ability of HSCs to become quiescent and also induced their adhesion to bone, protecting them from stresses that suppress hematopoiesis. These data suggest that the Ang-1/Tie2 signaling pathway plays a crucial role in the maintenance of HSCs in a quiescent state in the BM niche.

Original languageEnglish
Pages (from-to)139-140
Number of pages2
JournalCell
Volume118
Issue number2
DOIs
StatePublished - 23 Jul 2004
Externally publishedYes

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