Thymolipoma: clues to pathogenesis revealed by cytogenetics

Rachel Hudacko; Hana Aviv; John Langenfeld; Billie Fyfe

doi:10.1016/j.anndiagpath.2008.02.006

Thymolipoma: clues to pathogenesis revealed by cytogenetics

Rachel Hudacko, Hana Aviv, John Langenfeld, Billie Fyfe

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The pathogenesis of thymolipoma is controversial and unclear despite numerous reports. A case report of thymolipoma with cytogenetic analysis is herein presented. The lesion demonstrated a translocation involving the HMGA2 gene on chromosome 12q15, which is seen in two thirds of solitary lipomas. This finding supports the theory that this case of thymolipoma is a neoplasm of thymic fat.

Original language	English
Pages (from-to)	185-188
Number of pages	4
Journal	Annals of Diagnostic Pathology
Volume	13
Issue number	3
DOIs	https://doi.org/10.1016/j.anndiagpath.2008.02.006
State	Published - Jun 2009
Externally published	Yes

Keywords

HMGA2 gene
Lipoma
Thymolipoma
Thymus

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10.1016/j.anndiagpath.2008.02.006

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title = "Thymolipoma: clues to pathogenesis revealed by cytogenetics",

abstract = "The pathogenesis of thymolipoma is controversial and unclear despite numerous reports. A case report of thymolipoma with cytogenetic analysis is herein presented. The lesion demonstrated a translocation involving the HMGA2 gene on chromosome 12q15, which is seen in two thirds of solitary lipomas. This finding supports the theory that this case of thymolipoma is a neoplasm of thymic fat.",

keywords = "HMGA2 gene, Lipoma, Thymolipoma, Thymus",

author = "Rachel Hudacko and Hana Aviv and John Langenfeld and Billie Fyfe",

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AU - Hudacko, Rachel

AU - Aviv, Hana

AU - Langenfeld, John

AU - Fyfe, Billie

PY - 2009/6

Y1 - 2009/6

N2 - The pathogenesis of thymolipoma is controversial and unclear despite numerous reports. A case report of thymolipoma with cytogenetic analysis is herein presented. The lesion demonstrated a translocation involving the HMGA2 gene on chromosome 12q15, which is seen in two thirds of solitary lipomas. This finding supports the theory that this case of thymolipoma is a neoplasm of thymic fat.

AB - The pathogenesis of thymolipoma is controversial and unclear despite numerous reports. A case report of thymolipoma with cytogenetic analysis is herein presented. The lesion demonstrated a translocation involving the HMGA2 gene on chromosome 12q15, which is seen in two thirds of solitary lipomas. This finding supports the theory that this case of thymolipoma is a neoplasm of thymic fat.

KW - HMGA2 gene

KW - Lipoma

KW - Thymolipoma

KW - Thymus

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DO - 10.1016/j.anndiagpath.2008.02.006

M3 - Article

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AN - SCOPUS:67349120221

SN - 1092-9134

VL - 13

SP - 185

EP - 188

JO - Annals of Diagnostic Pathology

JF - Annals of Diagnostic Pathology

IS - 3

ER -

Thymolipoma: clues to pathogenesis revealed by cytogenetics

Abstract

Keywords

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