@article{d7d3a893ec5748099af60baa700af070,
title = "Thymic Stromal Lymphopoietin-Mediated Extramedullary Hematopoiesis Promotes Allergic Inflammation",
abstract = "Extramedullary hematopoiesis (EMH) refers to the differentiation of hematopoietic stem cells (HSCs) into effector cells that occurs in compartments outside of the bone marrow. Previous studies linked pattern-recognition receptor (PRR)-expressing HSCs, EMH, and immune responses to microbial stimuli. However, whether EMH operates in broader immune contexts remains unknown. Here, we demonstrate a previously unrecognized role for thymic stromal lymphopoietin (TSLP) in promoting the population expansion of progenitor cells in the periphery and identify that TSLP-elicited progenitors differentiated into effector cells including macrophages, dendritic cells, and granulocytes and that these cells contributed to type 2 cytokine responses. The frequency of circulating progenitor cells was also increased in allergic patients with a gain-of-function polymorphism in TSLP, suggesting the TSLP-EMH pathway might operate in human disease. These data identify that TSLP-induced EMH contributes to the development of allergic inflammation and indicate that EMH is a conserved mechanism of innate immunity.",
author = "Siracusa, {Mark C.} and Saenz, {Steven A.} and {Tait Wojno}, {Elia D.} and Kim, {Brian S.} and Osborne, {Lisa C.} and Ziegler, {Carly G.} and Benitez, {Alain J.} and Ruymann, {Kathryn R.} and Farber, {Donna L.} and Sleiman, {Patrick M.} and Hakon Hakonarson and Antonella Cianferoni and Wang, {Mei Lun} and Spergel, {Jonathan M.} and Comeau, {Michael R.} and David Artis",
note = "Funding Information: We thank members of the Artis laboratory for discussions and critical reading, and Kyle Bittinger for assistance with PCA analysis. This work is supported by the National Institutes of Health (AI061570, AI087990, AI074878, AI083480, AI095466, AI095608, AI102942, AI06697, and AI097333 to D.A.), the National Center for Research Resources and the National Center for Advancing Translational Sciences (KL2TR000139), the BWF Investigator in Pathogenesis of Infectious Disease Award (D.A.), and the CCFA (D.A.). Human spleen tissue samples were provided by the CHTN, which is funded by the NCI. Human PBMCs were provided by M.-L.W. and A.J.B, funded by Abbot Nutrition (ANUS1013). B.S.K. is funded by KL2-RR024132, and M.C.S. is funded by AI085828. M.R.C. is an employee and shareholder of Amgen. ",
year = "2013",
month = dec,
day = "12",
doi = "10.1016/j.immuni.2013.09.016",
language = "English",
volume = "39",
pages = "1158--1170",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "6",
}