Thymic carcinoma with metastasis in a 29-year-old male causing radiculopathy

Kirill Alekseyev; Armando Iannicello; Giuseppe Amore; Travis Rosenkranz; Marc K. Ross

doi:10.1093/omcr/omw046

Thymic carcinoma with metastasis in a 29-year-old male causing radiculopathy

Kirill Alekseyev, Armando Iannicello, Giuseppe Amore, Travis Rosenkranz, Marc K. Ross

Research output: Contribution to journal › Article › peer-review

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Abstract

Thymic carcinoma is a rare, aggressive neoplasmwith low5-year survival rates ranging from28 to 67%. Initial presentation with spinal or bone metastasis in primary thymic carcinoma is extremely rare. Thymic carcinoma, compared with thymoma, has higher recurrence rates and worse survival. We report one patient, a 29-year-old African-American male, with thymic carcinoma with metastasis to the epidural space (with cord compression), multiple bony structures (T10-L1) and left supraclavicular lymph node. Immunohistochemical staining was CD5 and c-Kit positive, consistent with thymic carcinoma. Patient underwent T12-L1 laminectomy with tumor resection to relieve cord compression and leg numbness/weakness. Patient was deemed a good candidate for rehabilitation. Soon after starting a rehabilitation program, he quickly demonstrated gains in gait distance with little to no assistance. Follow-up appointments with oncology were scheduled, and further planning of radiation and chemotherapy treatments were discussed.

Original language	English
Pages (from-to)	183-185
Number of pages	3
Journal	Oxford Medical Case Reports
Volume	2016
Issue number	8
DOIs	https://doi.org/10.1093/omcr/omw046
State	Published - 1 Aug 2017
Externally published	Yes

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abstract = "Thymic carcinoma is a rare, aggressive neoplasmwith low5-year survival rates ranging from28 to 67%. Initial presentation with spinal or bone metastasis in primary thymic carcinoma is extremely rare. Thymic carcinoma, compared with thymoma, has higher recurrence rates and worse survival. We report one patient, a 29-year-old African-American male, with thymic carcinoma with metastasis to the epidural space (with cord compression), multiple bony structures (T10-L1) and left supraclavicular lymph node. Immunohistochemical staining was CD5 and c-Kit positive, consistent with thymic carcinoma. Patient underwent T12-L1 laminectomy with tumor resection to relieve cord compression and leg numbness/weakness. Patient was deemed a good candidate for rehabilitation. Soon after starting a rehabilitation program, he quickly demonstrated gains in gait distance with little to no assistance. Follow-up appointments with oncology were scheduled, and further planning of radiation and chemotherapy treatments were discussed.",

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AU - Rosenkranz, Travis

AU - Ross, Marc K.

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AB - Thymic carcinoma is a rare, aggressive neoplasmwith low5-year survival rates ranging from28 to 67%. Initial presentation with spinal or bone metastasis in primary thymic carcinoma is extremely rare. Thymic carcinoma, compared with thymoma, has higher recurrence rates and worse survival. We report one patient, a 29-year-old African-American male, with thymic carcinoma with metastasis to the epidural space (with cord compression), multiple bony structures (T10-L1) and left supraclavicular lymph node. Immunohistochemical staining was CD5 and c-Kit positive, consistent with thymic carcinoma. Patient underwent T12-L1 laminectomy with tumor resection to relieve cord compression and leg numbness/weakness. Patient was deemed a good candidate for rehabilitation. Soon after starting a rehabilitation program, he quickly demonstrated gains in gait distance with little to no assistance. Follow-up appointments with oncology were scheduled, and further planning of radiation and chemotherapy treatments were discussed.

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Thymic carcinoma with metastasis in a 29-year-old male causing radiculopathy

Abstract

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