Thrombo-embolic prevention after transcatheter aortic valve implantation

Pascal Vranckx, Stephan Windecker, Robert C. Welsh, Marco Valgimigli, Roxana Mehran, George Dangas

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations


Transcatheter aortic valve implantation (TAVI) has emerged as a valuable treatment alternative to surgical aortic valve replacement among patients with symptomatic aortic stenosis at increased surgical risk. The rapid technological evolution from early to current-generation TAVI systems with low-profile delivery catheters, bioprosthetic valves with proven midterm durability, and improved positioning and retrieval features have made important contributions to the widespread clinical use of this minimal invasive therapy. Although periprocedural and long-term thrombotic and bleeding events after TAVI remain a relevant concern, the optimal antithrombotic strategy and duration to mitigate these risks remain unclear. This review provides an overview of recent insights in this field, and highlights current and future antithrombotic trials focusing on optimizing outcomes in patients undergoing TAVI.

Original languageEnglish
Pages (from-to)3341-3350
Number of pages10
JournalEuropean Heart Journal
Issue number45
StatePublished - 1 Dec 2017
Externally publishedYes


  • Anticoagulation
  • Aortic valve
  • TAVI


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