Three‐dimensional MRI microscopy of the normal rat brain

G. Allan Johnson; Morrow B. Thompson; Burton P. Drayer

doi:10.1002/mrm.1910040406

Three‐dimensional MRI microscopy of the normal rat brain

G. Allan Johnson, Morrow B. Thompson, Burton P. Drayer

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Magnetic resonance imaging techniques have been developed to enable imaging of the live rat brain with thin (1.2‐mm) slices and microscopic pixels (115 × 115 μm). Signal‐to‐noise ratios high enough to realize the microscopic resolution are obtained with of coils designed for the subject and through the use of three dimensional Fourier spin warp imaging. The technique yields 16 contiguous slices. Correlation with fixed pathologic specimens enables unequivocal identification of gray and white matter structures in the brain of a live 200‐g rat. Structures clearly visible in the MR images include Ammon's horn, the hypothalamus, corpus callosum and substantia nigra, as well as a number of brainstem nuclei. © 1987 Academic Press, Inc.

Original language	English
Pages (from-to)	351-365
Number of pages	15
Journal	Magnetic Resonance in Medicine
Volume	4
Issue number	4
DOIs	https://doi.org/10.1002/mrm.1910040406
State	Published - Apr 1987
Externally published	Yes

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title = "Three‐dimensional MRI microscopy of the normal rat brain",

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AB - Magnetic resonance imaging techniques have been developed to enable imaging of the live rat brain with thin (1.2‐mm) slices and microscopic pixels (115 × 115 μm). Signal‐to‐noise ratios high enough to realize the microscopic resolution are obtained with of coils designed for the subject and through the use of three dimensional Fourier spin warp imaging. The technique yields 16 contiguous slices. Correlation with fixed pathologic specimens enables unequivocal identification of gray and white matter structures in the brain of a live 200‐g rat. Structures clearly visible in the MR images include Ammon's horn, the hypothalamus, corpus callosum and substantia nigra, as well as a number of brainstem nuclei. © 1987 Academic Press, Inc.

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Three‐dimensional MRI microscopy of the normal rat brain

Abstract

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