Three-year outcomes of the Dissected Aorta Repair Through Stent Implantation trial

Sabin J. Bozso, Jeevan Nagendran, Michael W.A. Chu, Bob Kiaii, Ismail El-Hamamsy, Maral Ouzounian, Jessica Forcillo, Jörg Kempfert, Christoph Starck, Michael C. Moon

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Objective: The study objective was to evaluate the clinical and radiographic outcomes of the Ascyrus Medical Dissection Stent in a prospective, nonrandomized, international study (Dissected Aorta Repair Through Stent Implantation) of patients with acute DeBakey type I aortic dissection. Methods: The Ascyrus Medical Dissection Stent was used in combination with the standard surgical management of acute DeBakey type I aortic dissection I to treat patients with (56.5%, 26/46) and without (43.5%, 20/46) preoperative clinical and radiographic malperfusion. All patients had a primary entry tear in the ascending aorta, and 97.8% (45/46) were treated with a hemiarch repair. Median follow-up was 3 years. Results: All 47 patients underwent emergency surgical repair with successful Ascyrus Medical Dissection Stent implantation. One patient was excluded from analysis due to use in iatrogenic dissection. Overall mortality at 30 days and 3 years was 13.0% (6/46) and 21.7% (10/46), respectively. Overall new stroke rate at 30 days was 15.2% (7/46). No devices were explanted at any time during the 3-year median follow-up. At 3 years, the total aortic diameter in zones 0, 1, and 2 decreased or remained stable in 91.7%, 72.7%, and 75.0%, respectively. The false lumen was completely or partially thrombosed in 90.5% in zone 0, 60.0% in zone 1, and 68.2% in zone 2 at 3 years. Conclusions: The use of the Ascyrus Medical Dissection Stent in the treatment of acute DeBakey type I aortic dissection I holds promise as a simple technology that enables repair of the aortic arch and proximal descending aorta, while promoting positive aortic remodeling. Ongoing follow-up of the Dissected Aorta Repair Through Stent Implantation trial will provide long-term, prospective, clinical outcomes and radiographic data on positive remodeling of the aortic arch.

Original languageEnglish
Pages (from-to)1661-1669.e3
JournalJournal of Thoracic and Cardiovascular Surgery
Volume167
Issue number5
DOIs
StatePublished - May 2024
Externally publishedYes

Keywords

  • aorta
  • aortic dissection
  • endovascular

Fingerprint

Dive into the research topics of 'Three-year outcomes of the Dissected Aorta Repair Through Stent Implantation trial'. Together they form a unique fingerprint.

Cite this