Three-dimensional preoperative maps of hippocampal atrophy predict surgical outcomes in temporal lobe epilepsy

  • Jack J. Lin
  • , N. Salamon
  • , R. A. Dutton
  • , A. D. Lee
  • , J. A. Geaga
  • , K. M. Hayashi
  • , A. W. Toga
  • , J. Engel
  • , P. M. Thompson

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

The authors used surface-based anatomic mapping to detect features of hippocampal anatomy that correlated with surgical outcomes in patients undergoing surgery for mesial temporal lobe epilepsy with hippocampal sclerosis. Compared with a seizure-free group, hippocampal profiles for the non-seizure-free group had greater diffuse ipsilateral atrophy and more region-specific contralateral atrophy in the anterior, lateral hippocampus. These atrophic regions may indicate areas of increased epileptogenicity, contributing to poorer surgical outcomes.

Original languageEnglish
Pages (from-to)1094-1097
Number of pages4
JournalNeurology
Volume65
Issue number7
DOIs
StatePublished - 11 Oct 2005
Externally publishedYes

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