Three-dimensional finite element models from Magnetic resonance images as a structural framework for continuum analysis of the heart

Magnetic resonance imaging (MRI) is an extremely versatile technique for non-invasive imaging of the anatomy, structure and physiological function of the heart and other soft tissues and organs. Although mathematical models have often been used to enhance the information content of medical images, these models are most often based on the physics of the imaging system rather than the properties of the target organ or tissue. We use finite element (FE) models of regional mechanical and electrical function in the intact heart to compute three-dimensional distributions of important physiological field variables, such as myocardial stress, that cannot be imaged directly. A parametric model of the heart based on the physical properties of the organ as a material continuum provides a general and convenient way to synthesize clinical data, such as multi-dimensional images, with experimental tests, such as biomechanical and histological studies.