Theta rhythmopathy as a cause of cognitive disability in TLE

Tristan Shuman, Benjamin Amendolara, Peyman Golshani

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Memory difficulties are commonly associated with temporal lobe epilepsy (TLE) and cause significant disability. This article reviews the role of altered hippocampal theta oscillations and theta-gamma coupling as potential causes of memory disturbance in temporal lobe epilepsy, dissecting the potential mechanisms underlying these changes in large-scale neuronal synchronization. We discuss development of treatments for cognitive dysfunction directed at restoring theta rhythmicity and future directions for research.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalEpilepsy Currents
Issue number2
StatePublished - 2017
Externally publishedYes


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