Theta rhythmopathy as a cause of cognitive disability in TLE

Tristan Shuman, Benjamin Amendolara, Peyman Golshani

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Memory difficulties are commonly associated with temporal lobe epilepsy (TLE) and cause significant disability. This article reviews the role of altered hippocampal theta oscillations and theta-gamma coupling as potential causes of memory disturbance in temporal lobe epilepsy, dissecting the potential mechanisms underlying these changes in large-scale neuronal synchronization. We discuss development of treatments for cognitive dysfunction directed at restoring theta rhythmicity and future directions for research.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalEpilepsy Currents
Volume17
Issue number2
DOIs
StatePublished - 2017
Externally publishedYes

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