Therapy-related myelodysplastic/myeloproliferative neoplasms with del(5q) and t(1;11)(p32;q23) lacking MLL rearrangement

Katsuya Yamamoto, Yoshio Katayama, Manabu Shimoyama, Toshimitsu Matsui

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

A 69-year-old man was admitted because of macrocytic anemia and peripheral monocytosis: hemoglobin 75 g/L and white blood cells 16.0×109/L with 22% monocytes. Five years prior, he had received CHOP regimen and radiotherapy for diffuse large B-cell lymphoma. Bone marrow was hypercellular with trilineage dysplasia and 2.4% blasts. Chromosome analysis showed 46,XY,t(1;11)(p32;q23),del(5)(q13q35),+8,inv(9)(p11q 13),-15,-21,+mar1. These findings indicated a diagnosis of therapy-related myelodysplastic/myeloproliferative neoplasms (t-MDS/MPN). Fluorescence in situ hybridization revealed that the breakpoint at 11q23 was centromeric to the MLL gene. Taken together with the previously reported cases, trilineage dysplasia and del(5q) without MLL rearrangement suggests that alkylating agents may have a crucial role in the pathogenesis of t-MDS/MPN, which is a rare but recognizable entity.

Original languageEnglish
Pages (from-to)1031-1035
Number of pages5
JournalInternal Medicine
Volume49
Issue number11
DOIs
StatePublished - 2010
Externally publishedYes

Keywords

  • Chronic myelomonocytic leukemia
  • Deletion of the long arm of chromosome 5
  • MLL rearrangement
  • T(1;11)(p32;q23)
  • Therapy-related myelodysplastic/myeloproliferative neoplasms

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