Therapeutic uses of botulinum toxin

John A. Oates, Alastair J.j. Wood, Joseph Jankovic, Mitchell F. Brin

Research output: Contribution to journalReview articlepeer-review

779 Scopus citations

Abstract

BOTULISM had been recognized by the 18th century, but the observation that a toxin produced by an anaerobic organism might be responsible for food poisoning was not made until 1897.1 Although seven immunologically distinct toxins have since been identified, only types A, B, and E have been linked to cases of botulism in humans.2,3 Botulinum toxin type A (hereafter referred to as botulinum toxin), one of the most lethal biologic toxins, has been found to be of therapeutic value in the treatment of a variety of neurologic and ophthalmologic disorders.4 The Food and Drug Administration recently approved botulinum toxin (Oculinum).

Original languageEnglish
Pages (from-to)1186-1194
Number of pages9
JournalNew England Journal of Medicine
Volume324
Issue number17
DOIs
StatePublished - 25 Apr 1991
Externally publishedYes

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