TY - JOUR
T1 - Therapeutic uses of botulinum toxin
AU - Oates, John A.
AU - Wood, Alastair J.j.
AU - Jankovic, Joseph
AU - Brin, Mitchell F.
PY - 1991/4/25
Y1 - 1991/4/25
N2 - BOTULISM had been recognized by the 18th century, but the observation that a toxin produced by an anaerobic organism might be responsible for food poisoning was not made until 1897.1 Although seven immunologically distinct toxins have since been identified, only types A, B, and E have been linked to cases of botulism in humans.2,3 Botulinum toxin type A (hereafter referred to as botulinum toxin), one of the most lethal biologic toxins, has been found to be of therapeutic value in the treatment of a variety of neurologic and ophthalmologic disorders.4 The Food and Drug Administration recently approved botulinum toxin (Oculinum).
AB - BOTULISM had been recognized by the 18th century, but the observation that a toxin produced by an anaerobic organism might be responsible for food poisoning was not made until 1897.1 Although seven immunologically distinct toxins have since been identified, only types A, B, and E have been linked to cases of botulism in humans.2,3 Botulinum toxin type A (hereafter referred to as botulinum toxin), one of the most lethal biologic toxins, has been found to be of therapeutic value in the treatment of a variety of neurologic and ophthalmologic disorders.4 The Food and Drug Administration recently approved botulinum toxin (Oculinum).
UR - http://www.scopus.com/inward/record.url?scp=0025857556&partnerID=8YFLogxK
U2 - 10.1056/NEJM199104253241707
DO - 10.1056/NEJM199104253241707
M3 - Review article
C2 - 2011163
AN - SCOPUS:0025857556
SN - 0028-4793
VL - 324
SP - 1186
EP - 1194
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 17
ER -