Therapeutic implications of the emerging molecular biology of uveal melanoma

Mrinali Patel, Elizabeth Smyth, Paul B. Chapman, Jedd D. Wolchok, Gary K. Schwartz, David H. Abramson, Richard D. Carvajal

Research output: Contribution to journalArticlepeer-review

92 Scopus citations

Abstract

Uveal melanoma represents the most common primary intraocular malignancy in adults. Although uveal and cutaneous melanomas both arise from melanocytes, uveal melanoma is clinically and biologically distinct from its more common cutaneous counterpart. Metastasis occurs frequently in this disease, and once distant spread occurs, outcomes are poor. No effective systemic therapies are currently available; however, recent advances in our understanding of the biology of this rare and devastating disease, combined with the growing availability of targeted agents, which can be used to rationally exploit these findings, hold the promise for novel and effective therapies in the foreseeable future. Herein, we review our rapidly growing understanding of the molecular biology of uveal melanoma, including the pathogenic roles of GNAQ (guanine nucleotide binding protein q polypeptide)/11, PTEN (phosphatase and tensin homolog), IGF (insulin-like growth factor)/IGF-1 receptor, MET (hepatocyte growth factor), BAP1 [breast cancer 1, early onset (BRCA1)-associated protein-1], and other key molecules, potential therapeutic strategies derived from this emerging biology, and the next generation of recently initiated clinical trials for the treatment of advanced uveal melanoma.

Original languageEnglish
Pages (from-to)2087-2100
Number of pages14
JournalClinical Cancer Research
Volume17
Issue number8
DOIs
StatePublished - 15 Apr 2011
Externally publishedYes

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