Therapeutic effects of a fusogenic newcastle disease virus in treating head and neck cancer

Pingdong Li, Chun Hao Chen, Sen Li, Babak Givi, Zhenkun Yu, Dmitriy Zamarin, Peter Palese, Yuman Fong, Richard J. Wong

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Background Newcastle disease virus (NDV) is a paramyxovirus that is pathogenic in birds but causes only mild flulike symptoms in human beings. NDV(F3aa)-GFP is a genetically modified, fusogenic NDV. We assessed the utility of NDV(F3aa)-GFP in treating head and neck squamous cell carcinoma. Methods and Results At a multiplicity of infection (MOI) of 1, NDV(F3aa)-GFP infection of 3 cell lines supported strong GFP expression by 36 hours. Four cell lines were highly sensitivite to viral cytotoxicity, with >75% of cells lysed by day 6 at MOI 0.1, and 2 other cell lines were partially susceptible. Murine SCC25 flank tumors exhibited robust GFP expression after a single intratumoral viral injection and showed near-complete tumor regression over 34 days. There were no adverse effects attributable to therapy. Conclusions We demonstrate that a fusogenic NDV exerts potent oncolytic effects against human head and neck cancer and support its continued investigation for clinical application.

Original languageEnglish
Pages (from-to)1394-1399
Number of pages6
JournalHead and Neck
Issue number10
StatePublished - Oct 2011


  • Newcastle disease virus
  • head and neck cancer
  • oncolysis
  • viral therapy


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