Theophylline pharmacokinetics in pregnant and lactating rats

Y. Brandstetter, J. Kaplanski, C. Van Creveld, Z. Ben-Zvi

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


As a preliminary investigation to a human study, the authors examined the pharmacokinetics of theophylline in pregnant and lactating rats. Three groups of female rats - pregnant, lactating, and virgin controls were injected IP with theophylline solution. Pregnant rats eliminated theophylline at a slower rate than both lactating rats and virgin controls, resulting in a longer half life (t1/2) and lower clearance. The approximate volume of distribution (aVd) and extrapolated peak concentration (Cp(O)) in the 3 groups were not different.

Original languageEnglish
Pages (from-to)269-271
Number of pages3
JournalResearch Communications in Chemical Pathology and Pharmacology
Issue number2
StatePublished - 1986
Externally publishedYes


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