The value of 68Gallium-DOTATATE PET/CT in sinonasal neuroendocrine tumor management: A case series

Katherine Y. Liu; David Y. Goldrich; Sen J. Ninan; Andrey Filimonov; Hansen Lam; Satish Govindaraj; Alfred Marc Iloreta

doi:10.1002/hed.26695

The value of ⁶⁸Gallium-DOTATATE PET/CT in sinonasal neuroendocrine tumor management: A case series

Katherine Y. Liu, David Y. Goldrich, Sen J. Ninan, Andrey Filimonov, Hansen Lam, Satish Govindaraj, Alfred Marc Iloreta

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Background: ⁶⁸Gallium-DOTATATE (⁶⁸Ga-DOTATATE) is a somatostatin analog used as a PET tracer to successfully identify neuroendocrine tumors (NETs). Due to the rarity of sinonasal NETs, there are few recommendations for ⁶⁸Ga-DOTATATE imaging in these patients. Methods: We discussed the impact of ⁶⁸Ga-DOTATATE imaging on the management of six sinonasal NET cases and reviewed existing literature. Results: ⁶⁸Ga-DOTATATE PET/CT revealed an unknown primary in one case and identified metastatic disease in a primary sinonasal small cell neuroendocrine carcinoma (SNEC) patient missed on conventional imaging. In two esthesioneuroblastoma (ENB) patients, ⁶⁸Ga-DOTATATE detected abnormal radiotracer uptake not present on 18F-FDG PET/CT and identified a patient for treatment with ¹⁷⁷Lu-DOTATATE. Conclusions: This is the one of the first few reports, and the largest series to our knowledge, demonstrating the utility of ⁶⁸Ga-DOTATATE imaging for primary sinonasal SNEC and ENB. Further study is required to determine its role in sinonasal NET management.

Original language	English
Pages (from-to)	E30-E40
Journal	Head and Neck
Volume	43
Issue number	6
DOIs	https://doi.org/10.1002/hed.26695
State	Published - Jun 2021

Keywords

diagnostic imaging
esthesioneuroblastoma
gallium dotatate
neuroendocrine tumor
sinonasal small cell neuroendocrine tumor
somatostatin analog

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10.1002/hed.26695

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@article{20d444a3676d4b51a8f1874a131b7d88,

title = "The value of 68Gallium-DOTATATE PET/CT in sinonasal neuroendocrine tumor management: A case series",

abstract = "Background: 68Gallium-DOTATATE (68Ga-DOTATATE) is a somatostatin analog used as a PET tracer to successfully identify neuroendocrine tumors (NETs). Due to the rarity of sinonasal NETs, there are few recommendations for 68Ga-DOTATATE imaging in these patients. Methods: We discussed the impact of 68Ga-DOTATATE imaging on the management of six sinonasal NET cases and reviewed existing literature. Results: 68Ga-DOTATATE PET/CT revealed an unknown primary in one case and identified metastatic disease in a primary sinonasal small cell neuroendocrine carcinoma (SNEC) patient missed on conventional imaging. In two esthesioneuroblastoma (ENB) patients, 68Ga-DOTATATE detected abnormal radiotracer uptake not present on 18F-FDG PET/CT and identified a patient for treatment with 177Lu-DOTATATE. Conclusions: This is the one of the first few reports, and the largest series to our knowledge, demonstrating the utility of 68Ga-DOTATATE imaging for primary sinonasal SNEC and ENB. Further study is required to determine its role in sinonasal NET management.",

keywords = "diagnostic imaging, esthesioneuroblastoma, gallium dotatate, neuroendocrine tumor, sinonasal small cell neuroendocrine tumor, somatostatin analog",

author = "Liu, {Katherine Y.} and Goldrich, {David Y.} and Ninan, {Sen J.} and Andrey Filimonov and Hansen Lam and Satish Govindaraj and Iloreta, {Alfred Marc}",

note = "Publisher Copyright: {\textcopyright} 2021 Wiley Periodicals LLC.",

year = "2021",

month = jun,

doi = "10.1002/hed.26695",

language = "English",

volume = "43",

pages = "E30--E40",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "John Wiley & Sons Inc.",

number = "6",

}

TY - JOUR

T1 - The value of 68Gallium-DOTATATE PET/CT in sinonasal neuroendocrine tumor management

T2 - A case series

AU - Liu, Katherine Y.

AU - Goldrich, David Y.

AU - Ninan, Sen J.

AU - Filimonov, Andrey

AU - Lam, Hansen

AU - Govindaraj, Satish

AU - Iloreta, Alfred Marc

PY - 2021/6

Y1 - 2021/6

N2 - Background: 68Gallium-DOTATATE (68Ga-DOTATATE) is a somatostatin analog used as a PET tracer to successfully identify neuroendocrine tumors (NETs). Due to the rarity of sinonasal NETs, there are few recommendations for 68Ga-DOTATATE imaging in these patients. Methods: We discussed the impact of 68Ga-DOTATATE imaging on the management of six sinonasal NET cases and reviewed existing literature. Results: 68Ga-DOTATATE PET/CT revealed an unknown primary in one case and identified metastatic disease in a primary sinonasal small cell neuroendocrine carcinoma (SNEC) patient missed on conventional imaging. In two esthesioneuroblastoma (ENB) patients, 68Ga-DOTATATE detected abnormal radiotracer uptake not present on 18F-FDG PET/CT and identified a patient for treatment with 177Lu-DOTATATE. Conclusions: This is the one of the first few reports, and the largest series to our knowledge, demonstrating the utility of 68Ga-DOTATATE imaging for primary sinonasal SNEC and ENB. Further study is required to determine its role in sinonasal NET management.

AB - Background: 68Gallium-DOTATATE (68Ga-DOTATATE) is a somatostatin analog used as a PET tracer to successfully identify neuroendocrine tumors (NETs). Due to the rarity of sinonasal NETs, there are few recommendations for 68Ga-DOTATATE imaging in these patients. Methods: We discussed the impact of 68Ga-DOTATATE imaging on the management of six sinonasal NET cases and reviewed existing literature. Results: 68Ga-DOTATATE PET/CT revealed an unknown primary in one case and identified metastatic disease in a primary sinonasal small cell neuroendocrine carcinoma (SNEC) patient missed on conventional imaging. In two esthesioneuroblastoma (ENB) patients, 68Ga-DOTATATE detected abnormal radiotracer uptake not present on 18F-FDG PET/CT and identified a patient for treatment with 177Lu-DOTATATE. Conclusions: This is the one of the first few reports, and the largest series to our knowledge, demonstrating the utility of 68Ga-DOTATATE imaging for primary sinonasal SNEC and ENB. Further study is required to determine its role in sinonasal NET management.

KW - diagnostic imaging

KW - esthesioneuroblastoma

KW - gallium dotatate

KW - neuroendocrine tumor

KW - sinonasal small cell neuroendocrine tumor

KW - somatostatin analog

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