Background: 68Gallium-DOTATATE (68Ga-DOTATATE) is a somatostatin analog used as a PET tracer to successfully identify neuroendocrine tumors (NETs). Due to the rarity of sinonasal NETs, there are few recommendations for 68Ga-DOTATATE imaging in these patients. Methods: We discussed the impact of 68Ga-DOTATATE imaging on the management of six sinonasal NET cases and reviewed existing literature. Results: 68Ga-DOTATATE PET/CT revealed an unknown primary in one case and identified metastatic disease in a primary sinonasal small cell neuroendocrine carcinoma (SNEC) patient missed on conventional imaging. In two esthesioneuroblastoma (ENB) patients, 68Ga-DOTATATE detected abnormal radiotracer uptake not present on 18F-FDG PET/CT and identified a patient for treatment with 177Lu-DOTATATE. Conclusions: This is the one of the first few reports, and the largest series to our knowledge, demonstrating the utility of 68Ga-DOTATATE imaging for primary sinonasal SNEC and ENB. Further study is required to determine its role in sinonasal NET management.
- diagnostic imaging
- gallium dotatate
- neuroendocrine tumor
- sinonasal small cell neuroendocrine tumor
- somatostatin analog